DiaChemo Point-of-care microfluidic device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection

Summary

The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without clinical benefits.

We propose to develop a point-of-care device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection incorporated in microfluidic lab-on-chip device (optofluidics based) allowing the real-time drug monitoring. This will improve the therapeutic outcome and reduced health care costs.

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Web resources:	https://cordis.europa.eu/project/id/633635
Start date:	01-05-2015
End date:	31-10-2020
Total budget - Public funding:	5 240 708,13 Euro - 4 654 333,00 Euro