Summary
CARE brings together distinguished scientists and highly representative networks in the European region, including Russia, in the fight against HIV/TB/HCV. CARE research objectives are based on already established European cohort networks with extensive and longitudinal data and/or sample collections. Together with new data and sample collections and cohorts created during the project, CARE will produce high-level researchoutputs during the two years of the project timeframe.
The specific short term objectives are to:
● Discover and validate novel soluble biomarkers of MDR-TB treatment success and of pulmonary TB.
● Explore host genetic mechanisms of susceptibility to extrapulmonary TB.
● Analyse genotype to phenotype correlations in MDR-TB and develop a decision making support tool.
● Define epidemiology and pathways of drug-resistant HIV, including their relationship with HIV subtypes and TB coinfection to support an evidence-based introduction of INSTIs as part of first line antiretroviral therapy.
● Discover and validate host genomic variants influencing susceptibility to contracting AIDS and serious non-AIDS clinical events and adverse reactions to drugs.
● Derive best practice recommendations for DAA prioritisation strategies for HCV treatment.
The longer-term objective of CARE is to implement a research infrastructure that allows the expansion of activities beyond the funding frame, permitting the partners to share technology, protocols, structured data collections and knowledge.
Finally, CARE activities include realization of recommendations and intervention plans, communication to the stakeholders, dissemination and training activities in order to develop and distribute the highest expertise and competence throughout the European region for the containment of the epidemics.CARE is fully in line with the call topic and addresses all its subtopics. It involves a recognised Russian partner coordinating 5 top level institutions covering the regions of Russia.
The specific short term objectives are to:
● Discover and validate novel soluble biomarkers of MDR-TB treatment success and of pulmonary TB.
● Explore host genetic mechanisms of susceptibility to extrapulmonary TB.
● Analyse genotype to phenotype correlations in MDR-TB and develop a decision making support tool.
● Define epidemiology and pathways of drug-resistant HIV, including their relationship with HIV subtypes and TB coinfection to support an evidence-based introduction of INSTIs as part of first line antiretroviral therapy.
● Discover and validate host genomic variants influencing susceptibility to contracting AIDS and serious non-AIDS clinical events and adverse reactions to drugs.
● Derive best practice recommendations for DAA prioritisation strategies for HCV treatment.
The longer-term objective of CARE is to implement a research infrastructure that allows the expansion of activities beyond the funding frame, permitting the partners to share technology, protocols, structured data collections and knowledge.
Finally, CARE activities include realization of recommendations and intervention plans, communication to the stakeholders, dissemination and training activities in order to develop and distribute the highest expertise and competence throughout the European region for the containment of the epidemics.CARE is fully in line with the call topic and addresses all its subtopics. It involves a recognised Russian partner coordinating 5 top level institutions covering the regions of Russia.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/825673 |
| Start date: | 01-01-2019 |
| End date: | 30-06-2021 |
| Total budget - Public funding: | 3 266 842,00 Euro - 2 961 912,00 Euro |
Cordis data
Original description
CARE brings together distinguished scientists and highly representative networks in the European region, including Russia, in the fight against HIV/TB/HCV. CARE research objectives are based on already established European cohort networks with extensive and longitudinal data and/or sample collections. Together with new data and sample collections and cohorts created during the project, CARE will produce high-level researchoutputs during the two years of the project timeframe.The specific short term objectives are to:
● Discover and validate novel soluble biomarkers of MDR-TB treatment success and of pulmonary TB.
● Explore host genetic mechanisms of susceptibility to extrapulmonary TB.
● Analyse genotype to phenotype correlations in MDR-TB and develop a decision making support tool.
● Define epidemiology and pathways of drug-resistant HIV, including their relationship with HIV subtypes and TB coinfection to support an evidence-based introduction of INSTIs as part of first line antiretroviral therapy.
● Discover and validate host genomic variants influencing susceptibility to contracting AIDS and serious non-AIDS clinical events and adverse reactions to drugs.
● Derive best practice recommendations for DAA prioritisation strategies for HCV treatment.
The longer-term objective of CARE is to implement a research infrastructure that allows the expansion of activities beyond the funding frame, permitting the partners to share technology, protocols, structured data collections and knowledge.
Finally, CARE activities include realization of recommendations and intervention plans, communication to the stakeholders, dissemination and training activities in order to develop and distribute the highest expertise and competence throughout the European region for the containment of the epidemics.CARE is fully in line with the call topic and addresses all its subtopics. It involves a recognised Russian partner coordinating 5 top level institutions covering the regions of Russia.
Status
CLOSEDCall topic
SC1-BHC-21-2018Update Date
26-10-2022
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Organisations
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| EURESIST NETWORK GEIE (Coördinator)
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| "INSTITUTIA MEDICO-SANITARA PUBLICA - INSTITUTUL DE FTIZIOPNEUMOLOGIE ""CHIRIL DRAGANIUC"""
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| EBERHARD KARLS UNIVERSITAET TUEBINGEN (EKUT)
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| FEDERAL RESEARCH CENTRE FOR EPIDEMIOLOGY AND MICROBIOLOGY NAMED AFTERTHE HONORARY ACADEMICIAN N.F. G...
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| FEDERAL STATE INSTITUTION SAINT PETERSBURG RESEARCH INSTITUTE OF PHTHISIOPULMONOLOGY OF THE FEDERAL ...
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| FORSCHUNGSZENTRUM BORSTEL
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| IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
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| INFECTIOUS DISEASES, AIDS AND CLINICAL IMMUNOLOGY RESEARCH CENTER
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| KAROLINSKA INSTITUTET
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| KLINIKUM DER UNIVERSITAET ZU KOELN
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| REGION HOVEDSTADEN
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| STATE INSTITUTION PUBLIC HEALTH CENTER OF THE MINISTRY OF HEALTH OF UKRAINE
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| UNIVERSITA DEGLI STUDI DI SIENA
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| VIESOJI ISTAIGA VILNIAUS UNIVERSITETO LIGONINE SANTAROS KLINIKOS