METHYLOMIC | DNA methylation markers to predict treatment success of biologicals in Crohn’s disease.

Summary
Monoclonal antibodies have become a mainstay of therapy in common immune-mediated diseases (IMID) including Crohn’s disease (CD), rheumatoid arthritis (RA), and psoriasis (PsO). Current therapeutics include antibodies (“biologicals”) targeting inflammatory proteins such as Tumor Necrosis Factor (adalimumab), leukocyte trafficking (vedolizumab), or IL-12/IL-23 (ustekinumab). At present however, it cannot be predicted which biological will be effective in an individual patient, with only
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/101095449
Start date: 01-01-2023
End date: 31-12-2026
Total budget - Public funding: 9 376 995,25 Euro - 9 376 995,00 Euro
Cordis data

Original description

Monoclonal antibodies have become a mainstay of therapy in common immune-mediated diseases (IMID) including Crohn’s disease (CD), rheumatoid arthritis (RA), and psoriasis (PsO). Current therapeutics include antibodies (“biologicals”) targeting inflammatory proteins such as Tumor Necrosis Factor (adalimumab), leukocyte trafficking (vedolizumab), or IL-12/IL-23 (ustekinumab). At present however, it cannot be predicted which biological will be effective in an individual patient, with only

Status

SIGNED

Call topic

HORIZON-HLTH-2022-TOOL-11-01

Update Date

09-02-2023
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Horizon Europe
HORIZON.2 Global Challenges and European Industrial Competitiveness
HORIZON.2.1 Health
HORIZON.2.1.0 Cross-cutting call topics
HORIZON-HLTH-2022-TOOL-11
HORIZON-HLTH-2022-TOOL-11-01 Optimising effectiveness in patients of existing prescription drugs for major diseases (except cancer) with the use of biomarkers
HORIZON.2.1.5 Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine
HORIZON-HLTH-2022-TOOL-11
HORIZON-HLTH-2022-TOOL-11-01 Optimising effectiveness in patients of existing prescription drugs for major diseases (except cancer) with the use of biomarkers