PanThera | Targeting Epilepsy Ictogenesis Process Through Pannexin-1 Modulation

Summary
Epilepsy, affecting about 1% of the population, comprises a group of neurological disorders characterized by the periodic occurrence of seizures, which disrupt normal brain function. Despite treatment with current antiepileptic drugs, one third of epileptic patients are pharmacoresistant and most patients suffer from side effects, making it crucial to develop novel therapies. Current drugs indeed target channels and receptors involved in normal brain function, not specific to the disease.
Our academic work has recently identified a novel and innovative target for epilepsy. Our project thus aims at bringing to the market a new generation of antiepileptic drugs specifically targeting the disease.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/101069281
Start date: 01-10-2022
End date: 31-03-2024
Total budget - Public funding: - 150 000,00 Euro
Cordis data

Original description

Epilepsy, affecting about 1% of the population, comprises a group of neurological disorders characterized by the periodic occurrence of seizures, which disrupt normal brain function. Despite treatment with current antiepileptic drugs, one third of epileptic patients are pharmacoresistant and most patients suffer from side effects, making it crucial to develop novel therapies. Current drugs indeed target channels and receptors involved in normal brain function, not specific to the disease.
Our academic work has recently identified a novel and innovative target for epilepsy. Our project thus aims at bringing to the market a new generation of antiepileptic drugs specifically targeting the disease.

Status

SIGNED

Call topic

ERC-2022-POC1

Update Date

09-02-2023
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Horizon Europe
HORIZON.1 Excellent Science
HORIZON.1.1 European Research Council (ERC)
HORIZON.1.1.0 Cross-cutting call topics
ERC-2022-POC1 ERC PROOF OF CONCEPT GRANTS1
HORIZON.1.1.1 Frontier science
ERC-2022-POC1 ERC PROOF OF CONCEPT GRANTS1