Summary
Insufficient intake of iron is one of the most common micronutrient deficiencies, with almost one-third of reproductive-aged women suffering from anaemia. Iron fortification of food products is an important route towards addressing this issue, but it is a notoriously difficult problem as product quality is often strongly compromised. While current strategies succeed in addressing some aspects of this challenge, they are often inadequate from a holistic perspective. Resolving these issues will help address societal challenges related to iron deficiencies, provide personalised nutrition, and support the growing adoption of plant-based diets. The objective of this research program is to explore the novel approach based on functional materials from metal-organic frameworks (MOFs) derived from iron (Fe) and edible plant-derived organic molecules, which can function as safe and bioaccessible by-design colloidal delivery systems. The approach will be based on selecting suitable organic ligands from the family of edible, plant-based polyphenols and acids, and use them in safe concentrations as Fe-based MOFs with pH triggered solubility (i.e. reversal back to the mineral and organic ligand) in the gastrointestinal tract. To achieve this goal, the following specific objectives will be met by developing new edible MOFs, both homogeneous and core-shell morphology, from Fe and plant-derived polyphenols and acids and evaluating their reactivity (e.g. oxidation, discoloration) and bioaccessibility in food products. If successful, this approach will enable the design of high-quality, mineral-enriched, plant-based food products. The proposed research program will lead to an increase in high-impact Research & Innovation output in the field of nutritious and functional food, specifically addressing the issue of iron deficiency. The expanded skill set of the fellow will improve his future employability and career prospects, both in industrial and academic research areas.
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| Web resources: | https://cordis.europa.eu/project/id/101066383 |
| Start date: | 01-08-2022 |
| End date: | 31-07-2024 |
| Total budget - Public funding: | - 187 624,00 Euro |
Cordis data
Original description
Insufficient intake of iron is one of the most common micronutrient deficiencies, with almost one-third of reproductive-aged women suffering from anaemia. Iron fortification of food products is an important route towards addressing this issue, but it is a notoriously difficult problem as product quality is often strongly compromised. While current strategies succeed in addressing some aspects of this challenge, they are often inadequate from a holistic perspective. Resolving these issues will help address societal challenges related to iron deficiencies, provide personalised nutrition, and support the growing adoption of plant-based diets. The objective of this research program is to explore the novel approach based on functional materials from metal-organic frameworks (MOFs) derived from iron (Fe) and edible plant-derived organic molecules, which can function as safe and bioaccessible by-design colloidal delivery systems. The approach will be based on selecting suitable organic ligands from the family of edible, plant-based polyphenols and acids, and use them in safe concentrations as Fe-based MOFs with pH triggered solubility (i.e. reversal back to the mineral and organic ligand) in the gastrointestinal tract. To achieve this goal, the following specific objectives will be met by developing new edible MOFs, both homogeneous and core-shell morphology, from Fe and plant-derived polyphenols and acids and evaluating their reactivity (e.g. oxidation, discoloration) and bioaccessibility in food products. If successful, this approach will enable the design of high-quality, mineral-enriched, plant-based food products. The proposed research program will lead to an increase in high-impact Research & Innovation output in the field of nutritious and functional food, specifically addressing the issue of iron deficiency. The expanded skill set of the fellow will improve his future employability and career prospects, both in industrial and academic research areas.Status
SIGNEDCall topic
HORIZON-MSCA-2021-PF-01-01Update Date
09-02-2023
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