Summary
The proposed project aims to investigate the contribution of thalamocortical projections to high cognitive functions such as speech
processing, working memory and attention in sighted and unsighted populations. In the last decades, advances made in magnetic
resonance imaging (MRI) have shed light on the cortical regions subserving these processes. However, less research has investigated
the role of thalamocortical pathways in these high cognitive functions. This could be due to the lack of detailed probabilistic atlases of
the human thalamus or the small size of the thalamic nuclei as compared to regular voxel sizes. Therefore, the recent creation of the
first probabilistic atlas of the human thalamus (developed by the host group), opens the door to investigate to what extent
thalamocortical connections relate to speech processing, working memory and attentional abilities. We will further investigate
whether the involvement of thalamocortical projections in the abovementioned functions differ between sighted and unsighted
individuals, since research conducted in blind population has reported enhanced auditory processing at the thalamic level, altered
thalamocortical connectivity and superior skills in the previous cognitive functions. To address these scientific questions, we will use a
multimodal MRI approach that combines functional and structural MRI indexes with behavioral measures. Using regression models,
we will assess the degree to which thalamocortical connections help to further explain speech processing, working memory and
attentional abilities as opposed to just considering cortical indexes, as it was done in the past. The results of the present research
project may have important implications as they could open a new avenue at the theoretical level (updating pre-existing models on
cognitive neuroscience and creating new ones) and regarding their application (improving the diagnosis and treatment in cases of
aphasia, dementia or attentional deficits)
processing, working memory and attention in sighted and unsighted populations. In the last decades, advances made in magnetic
resonance imaging (MRI) have shed light on the cortical regions subserving these processes. However, less research has investigated
the role of thalamocortical pathways in these high cognitive functions. This could be due to the lack of detailed probabilistic atlases of
the human thalamus or the small size of the thalamic nuclei as compared to regular voxel sizes. Therefore, the recent creation of the
first probabilistic atlas of the human thalamus (developed by the host group), opens the door to investigate to what extent
thalamocortical connections relate to speech processing, working memory and attentional abilities. We will further investigate
whether the involvement of thalamocortical projections in the abovementioned functions differ between sighted and unsighted
individuals, since research conducted in blind population has reported enhanced auditory processing at the thalamic level, altered
thalamocortical connectivity and superior skills in the previous cognitive functions. To address these scientific questions, we will use a
multimodal MRI approach that combines functional and structural MRI indexes with behavioral measures. Using regression models,
we will assess the degree to which thalamocortical connections help to further explain speech processing, working memory and
attentional abilities as opposed to just considering cortical indexes, as it was done in the past. The results of the present research
project may have important implications as they could open a new avenue at the theoretical level (updating pre-existing models on
cognitive neuroscience and creating new ones) and regarding their application (improving the diagnosis and treatment in cases of
aphasia, dementia or attentional deficits)
Unfold all
/
Fold all
More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101103842 |
| Start date: | 01-09-2024 |
| End date: | 31-08-2026 |
| Total budget - Public funding: | - 181 152,00 Euro |
Cordis data
Original description
The proposed project aims to investigate the contribution of thalamocortical projections to high cognitive functions such as speechprocessing, working memory and attention in sighted and unsighted populations. In the last decades, advances made in magnetic
resonance imaging (MRI) have shed light on the cortical regions subserving these processes. However, less research has investigated
the role of thalamocortical pathways in these high cognitive functions. This could be due to the lack of detailed probabilistic atlases of
the human thalamus or the small size of the thalamic nuclei as compared to regular voxel sizes. Therefore, the recent creation of the
first probabilistic atlas of the human thalamus (developed by the host group), opens the door to investigate to what extent
thalamocortical connections relate to speech processing, working memory and attentional abilities. We will further investigate
whether the involvement of thalamocortical projections in the abovementioned functions differ between sighted and unsighted
individuals, since research conducted in blind population has reported enhanced auditory processing at the thalamic level, altered
thalamocortical connectivity and superior skills in the previous cognitive functions. To address these scientific questions, we will use a
multimodal MRI approach that combines functional and structural MRI indexes with behavioral measures. Using regression models,
we will assess the degree to which thalamocortical connections help to further explain speech processing, working memory and
attentional abilities as opposed to just considering cortical indexes, as it was done in the past. The results of the present research
project may have important implications as they could open a new avenue at the theoretical level (updating pre-existing models on
cognitive neuroscience and creating new ones) and regarding their application (improving the diagnosis and treatment in cases of
aphasia, dementia or attentional deficits)
Status
SIGNEDCall topic
HORIZON-MSCA-2022-PF-01-01Update Date
31-07-2023
Images
No images available.
Geographical location(s)
Search
