Summary
The amino moiety is a fundamental functional group with essential functions across the chemical and life sciences, including agrochemical and pharmaceutical research and manufacture, polymer chemistry, and biochemistry. Therefore, there is a well-acknowledged need for new and more sustainable methods to construct C-N bonds. Most procedures for C-N bond formation rely on the use of toxic and expensive transition metal catalysts, which are notoriously impeded by undesired β-hydride elimination and/or poor site selectivity. Consequently, the search for new and more sustainable catalytic paradigms in synthesis has shifted towards the main group elements. Bismuth was recently demonstrated to moonlight both as a noble or first row transition metal, displaying reactivity in 1-electron and 2-electron processes at will. This dichotomy in reactivity of low-valent Bi complexes could potentially be crucial in addressing the long-standing issues encountered in C–N bond formation. Thus, ClaN-Bi aims to discover and develop new catalytic C–N cross-coupling reactions to generate both aliphatic and aromatic amines by exploiting the new Bi(I)/(II)/(III) redox platform.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101105383 |
| Start date: | 01-05-2023 |
| End date: | 30-04-2025 |
| Total budget - Public funding: | - 173 847,00 Euro |
Cordis data
Original description
The amino moiety is a fundamental functional group with essential functions across the chemical and life sciences, including agrochemical and pharmaceutical research and manufacture, polymer chemistry, and biochemistry. Therefore, there is a well-acknowledged need for new and more sustainable methods to construct C-N bonds. Most procedures for C-N bond formation rely on the use of toxic and expensive transition metal catalysts, which are notoriously impeded by undesired β-hydride elimination and/or poor site selectivity. Consequently, the search for new and more sustainable catalytic paradigms in synthesis has shifted towards the main group elements. Bismuth was recently demonstrated to moonlight both as a noble or first row transition metal, displaying reactivity in 1-electron and 2-electron processes at will. This dichotomy in reactivity of low-valent Bi complexes could potentially be crucial in addressing the long-standing issues encountered in C–N bond formation. Thus, ClaN-Bi aims to discover and develop new catalytic C–N cross-coupling reactions to generate both aliphatic and aromatic amines by exploiting the new Bi(I)/(II)/(III) redox platform.Status
SIGNEDCall topic
HORIZON-MSCA-2022-PF-01-01Update Date
31-07-2023
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