Summary
The last five decades have been characterized by an increase in obesity and cardiometabolic diseases. Recent predictions indicate that more than 1 billion people will be obese by 2030 worldwide. Contrary to white adipose tissue, brown adipose tissue (BAT) dissipates energy as heat and has been considered an important target for treating obesity and cardiometabolic diseases. Nevertheless, little is known about the interaction between diet, of the most important modifiable risk factors for cardiometabolic diseases, with BAT function. To develop new weight-loss strategies, it is essential to understand how food intake modulates BAT function by interacting with endocrine factors and how this interaction affects diet-induced thermogenesis in lean individuals and those with obesity.
Recent data indicate that DIT is associated with BAT function and that gut hormones play an important part in the activation of BAT during the postprandial phase. Yet, the mechanism remains to be elucidated. Moreover, it is unclear whether DIT and cold-induced thermogenesis (CIT) share similar metabolic pathways and how the manipulation of food intake can affect BAT and, thus, energy expenditure.
The main aims of FoodBAT are to investigate how the acute intake of a mixed meal modulates gut hormones to stimulate diet-induced thermogenesis (DIT) and BAT oxidative metabolism and to understand how this interplay differs between lean and obese individuals. Also, we will investigate how a cold acclimation protocol affects this interaction to modulate DIT in individuals with obesity. Finally, FoodBAT will unravel the connections and differences between DIT and CIT by comparing the gene expression and mitochondrial respiration of brown adipocytes stimulated with either nutrient overload, isoproterenol, or a combination of both. These findings will be pivotal for the development of new pharmacological and non-pharmacological (lifestyle-related) strategies to combat obesity.
Recent data indicate that DIT is associated with BAT function and that gut hormones play an important part in the activation of BAT during the postprandial phase. Yet, the mechanism remains to be elucidated. Moreover, it is unclear whether DIT and cold-induced thermogenesis (CIT) share similar metabolic pathways and how the manipulation of food intake can affect BAT and, thus, energy expenditure.
The main aims of FoodBAT are to investigate how the acute intake of a mixed meal modulates gut hormones to stimulate diet-induced thermogenesis (DIT) and BAT oxidative metabolism and to understand how this interplay differs between lean and obese individuals. Also, we will investigate how a cold acclimation protocol affects this interaction to modulate DIT in individuals with obesity. Finally, FoodBAT will unravel the connections and differences between DIT and CIT by comparing the gene expression and mitochondrial respiration of brown adipocytes stimulated with either nutrient overload, isoproterenol, or a combination of both. These findings will be pivotal for the development of new pharmacological and non-pharmacological (lifestyle-related) strategies to combat obesity.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101108436 |
| Start date: | 01-05-2023 |
| End date: | 30-04-2025 |
| Total budget - Public funding: | - 215 534,00 Euro |
Cordis data
Original description
The last five decades have been characterized by an increase in obesity and cardiometabolic diseases. Recent predictions indicate that more than 1 billion people will be obese by 2030 worldwide. Contrary to white adipose tissue, brown adipose tissue (BAT) dissipates energy as heat and has been considered an important target for treating obesity and cardiometabolic diseases. Nevertheless, little is known about the interaction between diet, of the most important modifiable risk factors for cardiometabolic diseases, with BAT function. To develop new weight-loss strategies, it is essential to understand how food intake modulates BAT function by interacting with endocrine factors and how this interaction affects diet-induced thermogenesis in lean individuals and those with obesity.Recent data indicate that DIT is associated with BAT function and that gut hormones play an important part in the activation of BAT during the postprandial phase. Yet, the mechanism remains to be elucidated. Moreover, it is unclear whether DIT and cold-induced thermogenesis (CIT) share similar metabolic pathways and how the manipulation of food intake can affect BAT and, thus, energy expenditure.
The main aims of FoodBAT are to investigate how the acute intake of a mixed meal modulates gut hormones to stimulate diet-induced thermogenesis (DIT) and BAT oxidative metabolism and to understand how this interplay differs between lean and obese individuals. Also, we will investigate how a cold acclimation protocol affects this interaction to modulate DIT in individuals with obesity. Finally, FoodBAT will unravel the connections and differences between DIT and CIT by comparing the gene expression and mitochondrial respiration of brown adipocytes stimulated with either nutrient overload, isoproterenol, or a combination of both. These findings will be pivotal for the development of new pharmacological and non-pharmacological (lifestyle-related) strategies to combat obesity.
Status
SIGNEDCall topic
HORIZON-MSCA-2022-PF-01-01Update Date
31-07-2023
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