Summary
Differently from other DBS systems on the market, the AlphaDBS can be programmed with two different types of stimulation: conventional DBS, which is implemented also by other DBS systems, and adaptive DBS (aDBS) that automatically adjusts the energy delivered to patient using a biosignal, local field potential (LFP), in a close loop configuration. LFPs represent the synchronous presynaptic and postsynaptic activity of neuronal populations and can be recorded with the macro-electrodes routinely implanted for cDBS. In Parkinson Disease, LFPs (especially in beta-band) are specifically modulated by dopamine intake, movement execution and preparation, and that they encode non-motor functions, such as decision making. The beta band power represents the input variable to the adaptive algorithm, implemented by the AlphaDBS system, which, every second computes a new stimulation value.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/190186802 |
| Start date: | 01-03-2023 |
| End date: | 28-02-2025 |
| Total budget - Public funding: | 3 725 437,50 Euro - 2 499 999,00 Euro |
Cordis data
Original description
Differently from other DBS systems on the market, the AlphaDBS can be programmed with two different types of stimulation: conventional DBS, which is implemented also by other DBS systems, and adaptive DBS (aDBS) that automatically adjusts the energy delivered to patient using a biosignal, local field potential (LFP), in a close loop configuration. LFPs represent the synchronous presynaptic and postsynaptic activity of neuronal populations and can be recorded with the macro-electrodes routinely implanted for cDBS. In Parkinson Disease, LFPs (especially in beta-band) are specifically modulated by dopamine intake, movement execution and preparation, and that they encode non-motor functions, such as decision making. The beta band power represents the input variable to the adaptive algorithm, implemented by the AlphaDBS system, which, every second computes a new stimulation value.Status
SIGNEDCall topic
HORIZON-EIC-2022-ACCELERATOROPEN-01Update Date
31-07-2023
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