HILIGHT | Highly Integrated Versatile Laser Source enabling two-photon excitation in digital diagnostics and biomedical research

Summary
The overall objective of HILIGHT is to implement innovative solutions into versatile light sources and systems as tools for biomedical and healthcare applications centred around two-photon excitation fluorescence lifetime measurements and imaging microscopy. We propose two specific use cases: i) instantaneous digital histopathology and ii) biomedical research in the context of cancer research and diagnostics. HILIGHT proposes a miniaturised and versatile optical pulse burst source together with innovative sensing technology that will permit us to overcome those limitations in SoA instrumentation that often confine the use of two-photon microscopy and time-resolved detection to the specialist laboratory. We envisage that the HILIGHT innovations could disrupt activities in various fields and a range of market segments, including academic and research institutions, biotechnology, and medical facilities. These include applications targeted to improve our understanding of the molecular mechanisms of disease using in vivo, ex vivo, or 3D organotypic cultures, with the ultimate aim of developing better tools for fast and early diagnosis and more effective therapeutic interventions. HILIGHT is structured around nine work packages covering the whole value chain, coherently with the concept of the project standing on strong enabling technology foundations and targeting biophotonic and medical application domains. HILIGHT consortium is made up of five leading partners from various fields experienced in European collaborative projects and from five different European countries (FR, DE, IT, CH and UK). HILIGHT is built on several prior and ongoing successful collaborations between partners, which provides a strong guarantee for successful interaction within the consortium, and a smooth implementation of the workplan.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/101135034
Start date: 01-12-2023
End date: 30-11-2027
Total budget - Public funding: - 3 185 792,00 Euro
Cordis data

Original description

The overall objective of HILIGHT is to implement innovative solutions into versatile light sources and systems as tools for biomedical and healthcare applications centred around two-photon excitation fluorescence lifetime measurements and imaging microscopy. We propose two specific use cases: i) instantaneous digital histopathology and ii) biomedical research in the context of cancer research and diagnostics. HILIGHT proposes a miniaturised and versatile optical pulse burst source together with innovative sensing technology that will permit us to overcome those limitations in SoA instrumentation that often confine the use of two-photon microscopy and time-resolved detection to the specialist laboratory. We envisage that the HILIGHT innovations could disrupt activities in various fields and a range of market segments, including academic and research institutions, biotechnology, and medical facilities. These include applications targeted to improve our understanding of the molecular mechanisms of disease using in vivo, ex vivo, or 3D organotypic cultures, with the ultimate aim of developing better tools for fast and early diagnosis and more effective therapeutic interventions. HILIGHT is structured around nine work packages covering the whole value chain, coherently with the concept of the project standing on strong enabling technology foundations and targeting biophotonic and medical application domains. HILIGHT consortium is made up of five leading partners from various fields experienced in European collaborative projects and from five different European countries (FR, DE, IT, CH and UK). HILIGHT is built on several prior and ongoing successful collaborations between partners, which provides a strong guarantee for successful interaction within the consortium, and a smooth implementation of the workplan.

Status

SIGNED

Call topic

HORIZON-CL4-2023-DIGITAL-EMERGING-01-53

Update Date

12-03-2024
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Photonics Partnership
Photonics Partnership Call 2023
HORIZON-CL4-2023-DIGITAL-EMERGING-01-53 Versatile light sources and systems as tools for manufacturing and medical application (Photonics Partnership) (RIA)
Horizon Europe
HORIZON.2 Global Challenges and European Industrial Competitiveness
HORIZON.2.4 Digital, Industry and Space
HORIZON.2.4.0 Cross-cutting call topics
HORIZON-CL4-2023-DIGITAL-EMERGING-01
HORIZON-CL4-2023-DIGITAL-EMERGING-01-53 Versatile light sources and systems as tools for manufacturing and medical application (Photonics Partnership) (RIA)
HORIZON.2.4.2 Key Digital Technologies
HORIZON-CL4-2023-DIGITAL-EMERGING-01
HORIZON-CL4-2023-DIGITAL-EMERGING-01-53 Versatile light sources and systems as tools for manufacturing and medical application (Photonics Partnership) (RIA)