Summary
The major contribution to chemical waste accumulating in chemical industry is made by solvents – often organic solvents, potentially toxic or harmful for the environment. My ERC-StG Mechanocat targeted this challenge by removing solvents entirely from chemical processes using a concept called mechanochemistry. In Mechanocat I applied mechanochemistry and targeted the famous Suzuki-coupling reaction, being one of the most popular catalysis in chemistry. The breakthrough of the project was the utilization of a principle to this reaction that we denoted as “direct mechanocatalysis” (DM). Applying DM, the catalyst neither must be added as molecule or complex as in homogeneous catalysis nor as solid powder as in heterogeneous catalysis. The milling ball itself served as catalyst because it was made from the catalytic material. This allowed for the easiest ever-possible way of catalyst separation and reutilization – simply taking the milling ball out of the milling vessel.
Despite its great economic and ecological advantages, our principle has only been demonstrated on the scale of milligrams using conventional laboratory mills running in batch mode.
To advance DM from lab curiosity to true innovation, the ERC-PoC project MechanoExtrusion will thus transfer DM to a continuous process at larger scale by giving the experimental evidence that one of the most popular reactions in pharmaceutical/medical chemistry – the Suzuki coupling – can be conducted in a Pd-coated extruder applying 100 times upscaled substrate quantities. In order to show that DM can become a true alternative to conventional catalysis, MechanoExtrusion will further on quantify the economic and ecological metrics using life-cycle assessment and market analysis, it will target IP protection, create industrial partnership to establish a first joint project and elaborate a business plan for potential spin-off foundation.
Despite its great economic and ecological advantages, our principle has only been demonstrated on the scale of milligrams using conventional laboratory mills running in batch mode.
To advance DM from lab curiosity to true innovation, the ERC-PoC project MechanoExtrusion will thus transfer DM to a continuous process at larger scale by giving the experimental evidence that one of the most popular reactions in pharmaceutical/medical chemistry – the Suzuki coupling – can be conducted in a Pd-coated extruder applying 100 times upscaled substrate quantities. In order to show that DM can become a true alternative to conventional catalysis, MechanoExtrusion will further on quantify the economic and ecological metrics using life-cycle assessment and market analysis, it will target IP protection, create industrial partnership to establish a first joint project and elaborate a business plan for potential spin-off foundation.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101123089 |
| Start date: | 01-06-2023 |
| End date: | 30-11-2024 |
| Total budget - Public funding: | - 150 000,00 Euro |
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Original description
The major contribution to chemical waste accumulating in chemical industry is made by solvents – often organic solvents, potentially toxic or harmful for the environment. My ERC-StG Mechanocat targeted this challenge by removing solvents entirely from chemical processes using a concept called mechanochemistry. In Mechanocat I applied mechanochemistry and targeted the famous Suzuki-coupling reaction, being one of the most popular catalysis in chemistry. The breakthrough of the project was the utilization of a principle to this reaction that we denoted as “direct mechanocatalysis” (DM). Applying DM, the catalyst neither must be added as molecule or complex as in homogeneous catalysis nor as solid powder as in heterogeneous catalysis. The milling ball itself served as catalyst because it was made from the catalytic material. This allowed for the easiest ever-possible way of catalyst separation and reutilization – simply taking the milling ball out of the milling vessel.Despite its great economic and ecological advantages, our principle has only been demonstrated on the scale of milligrams using conventional laboratory mills running in batch mode.
To advance DM from lab curiosity to true innovation, the ERC-PoC project MechanoExtrusion will thus transfer DM to a continuous process at larger scale by giving the experimental evidence that one of the most popular reactions in pharmaceutical/medical chemistry – the Suzuki coupling – can be conducted in a Pd-coated extruder applying 100 times upscaled substrate quantities. In order to show that DM can become a true alternative to conventional catalysis, MechanoExtrusion will further on quantify the economic and ecological metrics using life-cycle assessment and market analysis, it will target IP protection, create industrial partnership to establish a first joint project and elaborate a business plan for potential spin-off foundation.
Status
SIGNEDCall topic
ERC-2023-POCUpdate Date
12-03-2024
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