Summary
Since its discovery in 2014, bidimensional black phosphorus has raised a great scientific attention due to its unique structure and several exceptional attributes, such as peculiar optical and mechanical properties, excellent biocompatibility and biodegradation, which make it particularly attractive for biomedical applications.
Our studies performed during ERC-Advanced Grant (2015-2019) “Phosphorene functionalization: a new platform for advanced multifunctional materials - PHOSFUN” demonstrated the possibility to produce at large scale 2D BP with high purity grade at low cost by liquid exfoliation of bulk crystalline BP.
In addition to its low toxicity, we have proved that SMART BP treatment, obtained using our proprietary production process, has anti-proliferative effects as well as anti-inflammatory and regenerative properties in prostate tumours that can disrupt the treatment approach. Prostate cancer is the second most common cancer in men worldwide with about 1.3 million cases in 2018 and about 379,000 new deaths are expected by 2040. This makes prostate cancer a major public health concern.
As also stated by the European Urology Association, there is a need for more effective and cheaper early treatment options (alternative to radiotherapy or radical prostatectomy) that can bring a substantial decrease of healthcare costs.
Given the positive outcomes of lab tests performed by the PoC team while investigating the application in the health domain, we propose a patented prostate cancer treatment based on few-layer black phosphorus, SMART BP, that is a non-radioactive smart nanomaterial with no side effects (no irradiation, no toxicity, self-regeneration), improving patient’s quality of life and provide considerable economic benefits.
Within PHOSMED we intend to validate the effects of 2D BP on in vivo animal model, moving from TRL 3 to TRL 5 and paving the way to future scalability for new generation of no irradiation/no-toxic nanomedicine solutions.
Our studies performed during ERC-Advanced Grant (2015-2019) “Phosphorene functionalization: a new platform for advanced multifunctional materials - PHOSFUN” demonstrated the possibility to produce at large scale 2D BP with high purity grade at low cost by liquid exfoliation of bulk crystalline BP.
In addition to its low toxicity, we have proved that SMART BP treatment, obtained using our proprietary production process, has anti-proliferative effects as well as anti-inflammatory and regenerative properties in prostate tumours that can disrupt the treatment approach. Prostate cancer is the second most common cancer in men worldwide with about 1.3 million cases in 2018 and about 379,000 new deaths are expected by 2040. This makes prostate cancer a major public health concern.
As also stated by the European Urology Association, there is a need for more effective and cheaper early treatment options (alternative to radiotherapy or radical prostatectomy) that can bring a substantial decrease of healthcare costs.
Given the positive outcomes of lab tests performed by the PoC team while investigating the application in the health domain, we propose a patented prostate cancer treatment based on few-layer black phosphorus, SMART BP, that is a non-radioactive smart nanomaterial with no side effects (no irradiation, no toxicity, self-regeneration), improving patient’s quality of life and provide considerable economic benefits.
Within PHOSMED we intend to validate the effects of 2D BP on in vivo animal model, moving from TRL 3 to TRL 5 and paving the way to future scalability for new generation of no irradiation/no-toxic nanomedicine solutions.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/963933 |
| Start date: | 01-12-2020 |
| End date: | 30-11-2022 |
| Total budget - Public funding: | - 150 000,00 Euro |
Cordis data
Original description
Since its discovery in 2014, bidimensional black phosphorus has raised a great scientific attention due to its unique structure and several exceptional attributes, such as peculiar optical and mechanical properties, excellent biocompatibility and biodegradation, which make it particularly attractive for biomedical applications.Our studies performed during ERC-Advanced Grant (2015-2019) “Phosphorene functionalization: a new platform for advanced multifunctional materials - PHOSFUN” demonstrated the possibility to produce at large scale 2D BP with high purity grade at low cost by liquid exfoliation of bulk crystalline BP.
In addition to its low toxicity, we have proved that SMART BP treatment, obtained using our proprietary production process, has anti-proliferative effects as well as anti-inflammatory and regenerative properties in prostate tumours that can disrupt the treatment approach. Prostate cancer is the second most common cancer in men worldwide with about 1.3 million cases in 2018 and about 379,000 new deaths are expected by 2040. This makes prostate cancer a major public health concern.
As also stated by the European Urology Association, there is a need for more effective and cheaper early treatment options (alternative to radiotherapy or radical prostatectomy) that can bring a substantial decrease of healthcare costs.
Given the positive outcomes of lab tests performed by the PoC team while investigating the application in the health domain, we propose a patented prostate cancer treatment based on few-layer black phosphorus, SMART BP, that is a non-radioactive smart nanomaterial with no side effects (no irradiation, no toxicity, self-regeneration), improving patient’s quality of life and provide considerable economic benefits.
Within PHOSMED we intend to validate the effects of 2D BP on in vivo animal model, moving from TRL 3 to TRL 5 and paving the way to future scalability for new generation of no irradiation/no-toxic nanomedicine solutions.
Status
CLOSEDCall topic
ERC-2020-POCUpdate Date
27-04-2024
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