Summary
The DNA damage response (DDR) is a set of cellular events that follow the generation of a DNA damage. We have previously discovered a novel class of small non-coding RNAs, named DNA damage RNAs (DDRNAs), which are necessary for the full DDR activation upon a DNA double-strand break generation. Our preliminary data show that also at damaged/dysfunctional telomeres telomeric transcrips are produced. By using antisense oligonucleotides (ASOs) targeting them, we aim at modulating DDR in cultured cells and in vivo in animal models.
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| Web resources: | https://cordis.europa.eu/project/id/737561 |
| Start date: | 01-03-2017 |
| End date: | 31-08-2018 |
| Total budget - Public funding: | 149 950,00 Euro - 149 950,00 Euro |
Cordis data
Original description
The DNA damage response (DDR) is a set of cellular events that follow the generation of a DNA damage. We have previously discovered a novel class of small non-coding RNAs, named DNA damage RNAs (DDRNAs), which are necessary for the full DDR activation upon a DNA double-strand break generation. Our preliminary data show that also at damaged/dysfunctional telomeres telomeric transcrips are produced. By using antisense oligonucleotides (ASOs) targeting them, we aim at modulating DDR in cultured cells and in vivo in animal models.Status
CLOSEDCall topic
ERC-PoC-2016Update Date
27-04-2024
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