Summary
Adolescent idiopathic scoliosis (AIS) is a 3D deformity of the spine affecting previously healthy children, substantially reducing their quality of life and creating a life-long burden of disease. Although it has been indentified since the time of Hippocrates (400 BC), we have not been able to rationally develop effective treatments and provide a cure for these children suffering from AIS because its cause and mechanism of disease are still unknown. ScoliStorm will create a paradigm shift in AIS research by uncovering its complex perfect storm of anatomical, biomechanical and mechanobiological causes in the intervertebral disc and exploring this disease mechanism whereby predictive triggers are identified that can be used for prevention and early treatment. We will study human subjects non-invasively through disease initiation and progression, creating for the first time a comprehensive dataset of healthy and scoliotic human spines that can be used for early detection and treatment of juvenile spine conditions. We will create safe non-radiographic accurate imaging of the osseous spine, available in most hospitals, which can become the standard for diagnosis and monitoring of osseous injury and disease in juveniles. We will develop high-throughput creation and use of subject specific in silico models, allowing simulation of organ and tissue function such that morphological imaging data can provide functional analysis of the patient for diagnosis and treatment. Mechanisms affecting tissue adaptation will be mapped and show that normal processes by their coincidence can create an aberrant response and disease, providing an explanation applicable for other multifactorial diseases. Thus, a unique dedicated and complete multidisciplinary process, combining 1) bioengineering analysis, exploiting imaging, in silico modeling, in vitro and ex vivo approaches in humans, and 2) clinical medicine, also applicable for exploring other multifactorial diseases, will be created.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101020004 |
| Start date: | 01-10-2021 |
| End date: | 30-09-2026 |
| Total budget - Public funding: | 2 743 750,00 Euro - 2 743 750,00 Euro |
Cordis data
Original description
Adolescent idiopathic scoliosis (AIS) is a 3D deformity of the spine affecting previously healthy children, substantially reducing their quality of life and creating a life-long burden of disease. Although it has been indentified since the time of Hippocrates (400 BC), we have not been able to rationally develop effective treatments and provide a cure for these children suffering from AIS because its cause and mechanism of disease are still unknown. ScoliStorm will create a paradigm shift in AIS research by uncovering its complex perfect storm of anatomical, biomechanical and mechanobiological causes in the intervertebral disc and exploring this disease mechanism whereby predictive triggers are identified that can be used for prevention and early treatment. We will study human subjects non-invasively through disease initiation and progression, creating for the first time a comprehensive dataset of healthy and scoliotic human spines that can be used for early detection and treatment of juvenile spine conditions. We will create safe non-radiographic accurate imaging of the osseous spine, available in most hospitals, which can become the standard for diagnosis and monitoring of osseous injury and disease in juveniles. We will develop high-throughput creation and use of subject specific in silico models, allowing simulation of organ and tissue function such that morphological imaging data can provide functional analysis of the patient for diagnosis and treatment. Mechanisms affecting tissue adaptation will be mapped and show that normal processes by their coincidence can create an aberrant response and disease, providing an explanation applicable for other multifactorial diseases. Thus, a unique dedicated and complete multidisciplinary process, combining 1) bioengineering analysis, exploiting imaging, in silico modeling, in vitro and ex vivo approaches in humans, and 2) clinical medicine, also applicable for exploring other multifactorial diseases, will be created.Status
SIGNEDCall topic
ERC-2020-ADGUpdate Date
27-04-2024
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