PanaMast | Development of non-antibiotic therapy for the treatment of bovine mastitis

Summary
Bovine Mastitis is a bacterial infection of the cow udder. It is the major problem in the dairy sector, causing losses of approximately €1.5Bn in Europe each year, with each case costing the farmer €285/case. Current treatments use conventional antibiotics. These solutions are not ideal:
- they are not always effective
- bacteria can gain resistance to the antibiotics
- for a period of time during and following treatment (the 'withdrawal period' which can be up to 9.5 days) the milk must be discarded to prevent entry of antibiotic residues into the human food chain
Additionally there is a growing pressure for the need for new antibacterial approaches in animal health to lessen the pressures on existing antibiotics for human usage.

PanaMast is a novel innovative non-antibiotic antimicrobial technology.We are seeking to develop a novel mastitis treatment based on this technology. It is effective against all bacteria tested in the lab, including antibiotic-resistant strains, such as MRSA. Additionally, bacteria have been unable to gain a resistance to PanaMast. PanaMast is composed of natural products, which have a proven safety and toxicity profile. As such, this non-antibiotic approach aims to be the Worlds first Zero-withdrawal product, allowing farmers to sell milk both during and following treatment, while delivering an effective treatment regimen. In preliminary field trials against mastitis caused by Staph. aureus, we have shown a 70% cure rate, compared to a 5-15% cure rate using conventional treatments. This has a range of advantages over current products, namely:
- effective against all bacteria
- ability to treat antibiotic-resistant bacteria
- no resistance to the product
- zero withdrawal period

PanaMast therefore has the potential to dramatically improve the way mastitis is treated, resulting in improved health of cows, lessening of economic losses to the farmer and the dairy sector, and provides a needed solution to the growing antibiotic crisis
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/709914
Start date: 01-12-2015
End date: 30-04-2016
Total budget - Public funding: 71 429,00 Euro - 50 000,00 Euro
Cordis data

Original description

Bovine Mastitis is a bacterial infection of the cow udder. It is the major problem in the dairy sector, causing losses of approximately €1.5Bn in Europe each year, with each case costing the farmer €285/case. Current treatments use conventional antibiotics. These solutions are not ideal:
- they are not always effective
- bacteria can gain resistance to the antibiotics
- for a period of time during and following treatment (the 'withdrawal period' which can be up to 9.5 days) the milk must be discarded to prevent entry of antibiotic residues into the human food chain
Additionally there is a growing pressure for the need for new antibacterial approaches in animal health to lessen the pressures on existing antibiotics for human usage.

PanaMast is a novel innovative non-antibiotic antimicrobial technology.We are seeking to develop a novel mastitis treatment based on this technology. It is effective against all bacteria tested in the lab, including antibiotic-resistant strains, such as MRSA. Additionally, bacteria have been unable to gain a resistance to PanaMast. PanaMast is composed of natural products, which have a proven safety and toxicity profile. As such, this non-antibiotic approach aims to be the Worlds first Zero-withdrawal product, allowing farmers to sell milk both during and following treatment, while delivering an effective treatment regimen. In preliminary field trials against mastitis caused by Staph. aureus, we have shown a 70% cure rate, compared to a 5-15% cure rate using conventional treatments. This has a range of advantages over current products, namely:
- effective against all bacteria
- ability to treat antibiotic-resistant bacteria
- no resistance to the product
- zero withdrawal period

PanaMast therefore has the potential to dramatically improve the way mastitis is treated, resulting in improved health of cows, lessening of economic losses to the farmer and the dairy sector, and provides a needed solution to the growing antibiotic crisis

Status

CLOSED

Call topic

BIOTEC-5b-2015-1

Update Date

27-10-2022
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Horizon 2020
H2020-EU.2. INDUSTRIAL LEADERSHIP
H2020-EU.2.1. INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
H2020-EU.2.1.4. INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology
H2020-SMEINST-1-2015
BIOTEC-5b-2015-1 SME boosting biotechnology-based industrial processes driving competitiveness and sustainability
H2020-EU.2.3. INDUSTRIAL LEADERSHIP - Innovation In SMEs
H2020-EU.2.3.1. Mainstreaming SME support, especially through a dedicated instrument
H2020-SMEINST-1-2015
BIOTEC-5b-2015-1 SME boosting biotechnology-based industrial processes driving competitiveness and sustainability