Summary
We perceive the world through a multitude of sensory stimuli simultaneously arriving through our five senses . The appropriate selection and integration of this information is crucial for survival. For instance if you are walking in a busy street while you are talking on your phone, not prioritizing the visual input of a car approaching over the voice on the phone may have fatal consequences. The importance of appropriate sensory selection becomes even more evident in cognitive disorders such as Autism Spectrum Disorders (ASD) or schizophrenia, where individuals are unable to properly filter or process simultaneous channels of sensory inputs. Despite its significance, our knowledge is very limited in understanding the neural mechanisms that allows us to select the relevant signals amongst myriads of simultaneous inputs.
My overarching goal in this project is to reveal neural circuits that allow the selection and processing of the right sensory information in the right context. I will first uncover how the sensory signal flow in a cortex-wide neural network is shaped by different behavioral relevance. Next, I will test whether the higher order thalamic nuclei, LP and Pom, mediate these context-dependent modulations of cortical dynamics. This will be done by using large-scale neural measurements of the dorsal neocortex in combination with rodent behavior and circuit dissection tools to reveal context-dependent cortical dynamics and to dissect underlying neural mechanisms. Findings of this project will reveal differential routing of sensory information across cortical networks and identify key brain regions that are involved in gating of behaviorally relevant sensory information. Furthermore the results and the approach will provide the basis to study circuit dysfunction in complex cognitive disorders.
My overarching goal in this project is to reveal neural circuits that allow the selection and processing of the right sensory information in the right context. I will first uncover how the sensory signal flow in a cortex-wide neural network is shaped by different behavioral relevance. Next, I will test whether the higher order thalamic nuclei, LP and Pom, mediate these context-dependent modulations of cortical dynamics. This will be done by using large-scale neural measurements of the dorsal neocortex in combination with rodent behavior and circuit dissection tools to reveal context-dependent cortical dynamics and to dissect underlying neural mechanisms. Findings of this project will reveal differential routing of sensory information across cortical networks and identify key brain regions that are involved in gating of behaviorally relevant sensory information. Furthermore the results and the approach will provide the basis to study circuit dysfunction in complex cognitive disorders.
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| Web resources: | https://cordis.europa.eu/project/id/101030640 |
| Start date: | 01-11-2021 |
| End date: | 31-10-2023 |
| Total budget - Public funding: | 178 320,00 Euro - 178 320,00 Euro |
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Original description
We perceive the world through a multitude of sensory stimuli simultaneously arriving through our five senses . The appropriate selection and integration of this information is crucial for survival. For instance if you are walking in a busy street while you are talking on your phone, not prioritizing the visual input of a car approaching over the voice on the phone may have fatal consequences. The importance of appropriate sensory selection becomes even more evident in cognitive disorders such as Autism Spectrum Disorders (ASD) or schizophrenia, where individuals are unable to properly filter or process simultaneous channels of sensory inputs. Despite its significance, our knowledge is very limited in understanding the neural mechanisms that allows us to select the relevant signals amongst myriads of simultaneous inputs.My overarching goal in this project is to reveal neural circuits that allow the selection and processing of the right sensory information in the right context. I will first uncover how the sensory signal flow in a cortex-wide neural network is shaped by different behavioral relevance. Next, I will test whether the higher order thalamic nuclei, LP and Pom, mediate these context-dependent modulations of cortical dynamics. This will be done by using large-scale neural measurements of the dorsal neocortex in combination with rodent behavior and circuit dissection tools to reveal context-dependent cortical dynamics and to dissect underlying neural mechanisms. Findings of this project will reveal differential routing of sensory information across cortical networks and identify key brain regions that are involved in gating of behaviorally relevant sensory information. Furthermore the results and the approach will provide the basis to study circuit dysfunction in complex cognitive disorders.
Status
CLOSEDCall topic
MSCA-IF-2020Update Date
28-04-2024
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