Summary
Investigating the complex structure and functioning of biological systems through light microscopy represents a foundational pillar of the life sciences. However, the very complexity of the samples cellular structure leads to one of the main limitations of optical microscopy: light scattering confines it to the outer most tissue layers. In the past decades, multiphoton microscopy successfully extended the accessible depth ranges and on a different front, advances in optical wavefront shaping showed that scattering can be compensated for, even in regimes where light fully lost its initial directionality. The aim of this action is to establish scattering correction through wavefront shaping in higher-order multiphoton microscopy, namely three-photon fluorescence imaging, to surpass the scattering barrier and reach unprecedented depths in optical microscopy.
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| Web resources: | https://cordis.europa.eu/project/id/888707 |
| Start date: | 01-07-2020 |
| End date: | 30-06-2022 |
| Total budget - Public funding: | 184 707,84 Euro - 184 707,00 Euro |
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Original description
Investigating the complex structure and functioning of biological systems through light microscopy represents a foundational pillar of the life sciences. However, the very complexity of the samples cellular structure leads to one of the main limitations of optical microscopy: light scattering confines it to the outer most tissue layers. In the past decades, multiphoton microscopy successfully extended the accessible depth ranges and on a different front, advances in optical wavefront shaping showed that scattering can be compensated for, even in regimes where light fully lost its initial directionality. The aim of this action is to establish scattering correction through wavefront shaping in higher-order multiphoton microscopy, namely three-photon fluorescence imaging, to surpass the scattering barrier and reach unprecedented depths in optical microscopy.Status
CLOSEDCall topic
MSCA-IF-2019Update Date
28-04-2024
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