Neuralase | Nanolasers for in-vivo deep in tissue neuron activation and action potential sensing

Summary
Summary
Nanolasers offer the ultimate photonic gadget with unique properties as biosensors and actuators. Lasers at the nanoscale can concentrate high optical powers in small volumes and use a fraction of the power required to drive a conventional laser. Recently, nanolasers and nanoresonators have seen use for biosensing, with the focus so far on in-vitro biochemistry. Translating this approach to in-vivo is complex but promises to link relevant in-vivo physiological information with chemical pathways. This project aims to integrate photonic architectures for in-vivo deep-tissue exploration and to translate this technology to areas where probing the local environment with light has an immediate impact, such as the Brain. My proposed research thus bridges different scientific disciplines exploring the physics of biological sensing.
I foresee 3 major efforts to succeed in this research:
1 – Design of micro- and nanocavities operating in the IR.
2 – In vitro characterization through highly scattering media.
3 – In vivo investigations for deep-tissue sensing.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/101023747
Start date: 10-06-2021
End date: 09-01-2024
Total budget - Public funding: 174 806,40 Euro - 174 806,00 Euro
Cordis data

Original description

Summary
Nanolasers offer the ultimate photonic gadget with unique properties as biosensors and actuators. Lasers at the nanoscale can concentrate high optical powers in small volumes and use a fraction of the power required to drive a conventional laser. Recently, nanolasers and nanoresonators have seen use for biosensing, with the focus so far on in-vitro biochemistry. Translating this approach to in-vivo is complex but promises to link relevant in-vivo physiological information with chemical pathways. This project aims to integrate photonic architectures for in-vivo deep-tissue exploration and to translate this technology to areas where probing the local environment with light has an immediate impact, such as the Brain. My proposed research thus bridges different scientific disciplines exploring the physics of biological sensing.
I foresee 3 major efforts to succeed in this research:
1 – Design of micro- and nanocavities operating in the IR.
2 – In vitro characterization through highly scattering media.
3 – In vivo investigations for deep-tissue sensing.

Status

TERMINATED

Call topic

MSCA-IF-2020

Update Date

28-04-2024
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Horizon 2020
H2020-EU.1. EXCELLENT SCIENCE
H2020-EU.1.3. EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions (MSCA)
H2020-EU.1.3.2. Nurturing excellence by means of cross-border and cross-sector mobility
H2020-MSCA-IF-2020
MSCA-IF-2020 Individual Fellowships