LYMPHOSIGN | Integrated study of the role of B-cell receptor signaling in the development of Follicular Lymphoma

Summary
"Signaling through the B cell receptor (BCR) is central to the development and maintenance of B cells. In light of the
numerous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B
cells would co-opt this receptor to promote their own growth and survival. However, direct evidence for BCR signaling in
human lymphoma has only come to light recently. In this proposal, I aim to better understand the role for antigen-dependent vs. antigen-dependent BCR signaling as a pathogenic mechanism in the progression of Follicular lymphoma (FL), a indolent lymphoid malignancy that retain BCR expression during malignant progression. Further investigating the intrinsic role of BCR might lead to the development of new therapeutic approaches based on the inhibition of the BCR pathways. Using an innovative loss-of -function RNA interference genetic screen together with an engineered in vitro system allowing to test FL patients's BCR reactivity and identify putative ligands, we will 1) determine whether BCR signalling in FL relies to
""chronic active"" or ""tonic"" signals and 2) identify the nature of antigen(s) recognized by FL's BCR that may sustain
signalling; each signalling pathway offering different opportunities for therapeutic intervention.
For this project, I decided to chose the Louis Staudt’s group at the National Cancer Institute (NIH) for the outgoing phase since his group has been looking for years how to target B-cell receptor signaling as a treatment strategy. The unique expertise in the state-of the art functional genomic methodologies acquired during my stay at the NCI will be crucial for setting-up new scientific projects, promote extended collaborations and strongly support my re-establishement in Europe to reach an independent position.
"
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/661066
Start date: 01-12-2015
End date: 31-10-2018
Total budget - Public funding: 200 119,50 Euro - 200 119,00 Euro
Cordis data

Original description

"Signaling through the B cell receptor (BCR) is central to the development and maintenance of B cells. In light of the
numerous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B
cells would co-opt this receptor to promote their own growth and survival. However, direct evidence for BCR signaling in
human lymphoma has only come to light recently. In this proposal, I aim to better understand the role for antigen-dependent vs. antigen-dependent BCR signaling as a pathogenic mechanism in the progression of Follicular lymphoma (FL), a indolent lymphoid malignancy that retain BCR expression during malignant progression. Further investigating the intrinsic role of BCR might lead to the development of new therapeutic approaches based on the inhibition of the BCR pathways. Using an innovative loss-of -function RNA interference genetic screen together with an engineered in vitro system allowing to test FL patients's BCR reactivity and identify putative ligands, we will 1) determine whether BCR signalling in FL relies to
""chronic active"" or ""tonic"" signals and 2) identify the nature of antigen(s) recognized by FL's BCR that may sustain
signalling; each signalling pathway offering different opportunities for therapeutic intervention.
For this project, I decided to chose the Louis Staudt’s group at the National Cancer Institute (NIH) for the outgoing phase since his group has been looking for years how to target B-cell receptor signaling as a treatment strategy. The unique expertise in the state-of the art functional genomic methodologies acquired during my stay at the NCI will be crucial for setting-up new scientific projects, promote extended collaborations and strongly support my re-establishement in Europe to reach an independent position.
"

Status

CLOSED

Call topic

MSCA-IF-2014-GF

Update Date

28-04-2024
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Horizon 2020
H2020-EU.1. EXCELLENT SCIENCE
H2020-EU.1.3. EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions (MSCA)
H2020-EU.1.3.2. Nurturing excellence by means of cross-border and cross-sector mobility
H2020-MSCA-IF-2014
MSCA-IF-2014-GF Marie Skłodowska-Curie Individual Fellowships (IF-GF)