Summary
One the most relevant neuromodulator which affect the organisms’ ability to adapt to environmental changes and to aversive events is serotonin or 5-hydroxytryptamine (5-HT). 5-HT has long and widely been implicated in the pathophysiology of several psychiatric diseases such as obsessive-compulsive disorder, anxiety, drug addiction and depression. Emerging evidence indicate that 5-HT also plays a crucial role in cognitive and behavioral flexibility. Serotonin neurons respond to aversive stimuli and promote shifting behavior away from aversive events or frustrative non-reward but also respond to reward and prevent shifting behavior in the face of effort or delay. How 5-HT neurons from the dorsal raphe (DRN5-HT) both promote and prevent shifting behavior is, however, still unclear. Addressing this question requires a better understanding of the role of the 5-HT systems in controlling flexible behavior. Using calcium imaging, optogenetic manipulation, high density fiber photometry and closed-loop brain manipulation, in a comprehensive procedure assessing behavioral flexibility, FLEX5 aims to define the behavioral events that activate DRN5-HT neurons and define the role of 5-HT in its network.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/898308 |
| Start date: | 01-09-2020 |
| End date: | 31-08-2022 |
| Total budget - Public funding: | 171 473,28 Euro - 171 473,00 Euro |
Cordis data
Original description
One the most relevant neuromodulator which affect the organisms’ ability to adapt to environmental changes and to aversive events is serotonin or 5-hydroxytryptamine (5-HT). 5-HT has long and widely been implicated in the pathophysiology of several psychiatric diseases such as obsessive-compulsive disorder, anxiety, drug addiction and depression. Emerging evidence indicate that 5-HT also plays a crucial role in cognitive and behavioral flexibility. Serotonin neurons respond to aversive stimuli and promote shifting behavior away from aversive events or frustrative non-reward but also respond to reward and prevent shifting behavior in the face of effort or delay. How 5-HT neurons from the dorsal raphe (DRN5-HT) both promote and prevent shifting behavior is, however, still unclear. Addressing this question requires a better understanding of the role of the 5-HT systems in controlling flexible behavior. Using calcium imaging, optogenetic manipulation, high density fiber photometry and closed-loop brain manipulation, in a comprehensive procedure assessing behavioral flexibility, FLEX5 aims to define the behavioral events that activate DRN5-HT neurons and define the role of 5-HT in its network.Status
CLOSEDCall topic
MSCA-IF-2019Update Date
28-04-2024
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