Summary
This WiseCure Fellowship aims to bring novel wireless, scalable, MRI-compatible, and bio-integrated neural implants for optogenetics to treat epilepsy. Neurological diseases such as epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure). The ability to decipher brain functions and understand the neuronal communication networking properties to develop innovative solutions to treat neurological diseases remains one of the biggest challenges to date. A recent approach to study the brain is optogenetics. Optogenetics is a neural modulation technique which utilizes light to stimulate genetically engineered neurons, providing a better option for controlling the cells compared to conventional electrical stimulation. Scientists pursuing optogenetic therapies still face some technical challenges (e.g. size and multifunctional capability, biointegration, wireless capability, Magnetic Resonance Imaging (MRI) compatibility) that keeping optogenetics from clinical trials for brain diseases. I will combine the innovative wireless power transfer (WPT) approaches with ultrathin, soft and flexible biocompatible polymeric platforms to fabricate and characterize neural implants that are small enough to promote scalability, chronic reliability, and MRI compatibility. By associating the ability to wirelessly monitor (e.g. neural activities) and control (stimulation or inhibition) through these neural implants using a smartphone establishes a novel approach for versatile optogenetics to treat epilepsy. This Fellowship will act as a platform to realize my futuristic vision by integrating the wireless optogenetics system into smart healthcare using mobile and electronic technology for better diagnosis of the brain diseases, improved treatment of the patients, and enhanced quality of lives.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/893822 |
| Start date: | 01-09-2020 |
| End date: | 31-10-2022 |
| Total budget - Public funding: | 224 933,76 Euro - 224 933,00 Euro |
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Original description
This WiseCure Fellowship aims to bring novel wireless, scalable, MRI-compatible, and bio-integrated neural implants for optogenetics to treat epilepsy. Neurological diseases such as epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure). The ability to decipher brain functions and understand the neuronal communication networking properties to develop innovative solutions to treat neurological diseases remains one of the biggest challenges to date. A recent approach to study the brain is optogenetics. Optogenetics is a neural modulation technique which utilizes light to stimulate genetically engineered neurons, providing a better option for controlling the cells compared to conventional electrical stimulation. Scientists pursuing optogenetic therapies still face some technical challenges (e.g. size and multifunctional capability, biointegration, wireless capability, Magnetic Resonance Imaging (MRI) compatibility) that keeping optogenetics from clinical trials for brain diseases. I will combine the innovative wireless power transfer (WPT) approaches with ultrathin, soft and flexible biocompatible polymeric platforms to fabricate and characterize neural implants that are small enough to promote scalability, chronic reliability, and MRI compatibility. By associating the ability to wirelessly monitor (e.g. neural activities) and control (stimulation or inhibition) through these neural implants using a smartphone establishes a novel approach for versatile optogenetics to treat epilepsy. This Fellowship will act as a platform to realize my futuristic vision by integrating the wireless optogenetics system into smart healthcare using mobile and electronic technology for better diagnosis of the brain diseases, improved treatment of the patients, and enhanced quality of lives.Status
CLOSEDCall topic
MSCA-IF-2019Update Date
28-04-2024
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