RESOLVE | antibiotic RESistance and mObile genetic eLements dissemination in enVironmEntal conditions

Summary
Multidrug-resistant bacteria are spreading worldwide and present a serious public health issue. Bacterial resistance has to be addressed with a global approach connecting human health with animals and the environment. Mobile genetic elements (MGEs) such as bacterial plasmids, transposons or cassettes of integrons, as frequent carriers of antibiotic resistance genes (ARGs), play an important role in the global spread of ARGs among bacterial communities. My research aims to understand how environmental parameters could modulate the dynamics of MGEs involved in ARG dissemination and contribute to the global burden of antibiotic resistance. For this aim, I will use a global approach that merges medical and molecular microbiology, microbiota studies and genomic studies (employing next generation sequencing techniques). Single monospecies-biofilms as well as natural biofilms grown from wastewaters will be used as models of investigation. The proposed research will profoundly improve my knowledge in molecular and medical microbiology techniques to study MGEs associated with antibiotic resistance. This project will be pivotal for my personal development to become an independent researcher and will provide me with the unique opportunity to work with experts in the field of MGEs, antibiotic resistance and the environment. I will be exposed to novel ideas and input from renowned researchers belonging to scientific disciplines unrelated to my background that will have a strong impact on my personal and scientific development. Furthermore, I aim to establish a series of lectures and seminars for the general (research) community to further increase awareness of the importance and relevance of the global fight against antibiotic resistance.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/707999
Start date: 01-08-2016
End date: 31-07-2018
Total budget - Public funding: 173 076,00 Euro - 173 076,00 Euro
Cordis data

Original description

Multidrug-resistant bacteria are spreading worldwide and present a serious public health issue. Bacterial resistance has to be addressed with a global approach connecting human health with animals and the environment. Mobile genetic elements (MGEs) such as bacterial plasmids, transposons or cassettes of integrons, as frequent carriers of antibiotic resistance genes (ARGs), play an important role in the global spread of ARGs among bacterial communities. My research aims to understand how environmental parameters could modulate the dynamics of MGEs involved in ARG dissemination and contribute to the global burden of antibiotic resistance. For this aim, I will use a global approach that merges medical and molecular microbiology, microbiota studies and genomic studies (employing next generation sequencing techniques). Single monospecies-biofilms as well as natural biofilms grown from wastewaters will be used as models of investigation. The proposed research will profoundly improve my knowledge in molecular and medical microbiology techniques to study MGEs associated with antibiotic resistance. This project will be pivotal for my personal development to become an independent researcher and will provide me with the unique opportunity to work with experts in the field of MGEs, antibiotic resistance and the environment. I will be exposed to novel ideas and input from renowned researchers belonging to scientific disciplines unrelated to my background that will have a strong impact on my personal and scientific development. Furthermore, I aim to establish a series of lectures and seminars for the general (research) community to further increase awareness of the importance and relevance of the global fight against antibiotic resistance.

Status

CLOSED

Call topic

MSCA-IF-2015-EF

Update Date

28-04-2024
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Horizon 2020
H2020-EU.1. EXCELLENT SCIENCE
H2020-EU.1.3. EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions (MSCA)
H2020-EU.1.3.2. Nurturing excellence by means of cross-border and cross-sector mobility
H2020-MSCA-IF-2015
MSCA-IF-2015-EF Marie Skłodowska-Curie Individual Fellowships (IF-EF)