GELNANODEP | A gel-network depot for bringing advance strategies for skin cancer

Summary
GELNANODEP aims at inserting in the background of the advance drug delivery systems an innovative clinical treatment for skin cancer diseases as melanoma. The main goal of GELNANODEP system is to exploit a synergic therapeutic anticancer approach by using a gel depot loaded natural bacteriophages and a natural bio compound encapsulated with surface engineering nanoparticles. This project intends to propose a novel and alternative approach to avoid the usual severe side-effects affected by the systemic administration of the anticancer pharmaceuticals (e.g., intravenous injections or oral). So, the transdermal drug delivery system is proposed as alternatives that offer promising strategies for the treatment of skin tumours. Melanoma is a skin cancer which can become metastatic, drug-refractory, and lethal if managed late or inappropriately. Besides these already complicated conditions, it is largely known how the depletion of the immunological defence system of the cancer patient can induce infections by opportunist microbial pathogens such as bacteria and fungi. Pathogenic microorganisms with cancers have been reported frequently associated with chronic inflammation in skin malignancies, which can promote skin carcinogenesis inducing the ulceration of cutaneous lesions, and last but not list increasing patient mortality.
The GELNANODEP system provides a depot based on a thermosensitive biodegradable and biocompatible triblock copolymer carrying: (I) surface engineered nanoparticles to specific target alpha 2-beta-3 integrin expressed on tumour cells and selective release sulforaphane which is a natural dietary isothiocyanate mostly characterized by its potent anticancer activity, and (II) naturally bacteriophages inducing the death of pathogenic bacteria.
This proposal will be pursued by a highly interdisciplinary skills, composed of pharmaceutics, polymer chemistry, biology, molecular biology, oncology, clinicals and microbiology.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/101029908
Start date: 01-09-2021
End date: 31-08-2023
Total budget - Public funding: 187 572,48 Euro - 187 572,00 Euro
Cordis data

Original description

GELNANODEP aims at inserting in the background of the advance drug delivery systems an innovative clinical treatment for skin cancer diseases as melanoma. The main goal of GELNANODEP system is to exploit a synergic therapeutic anticancer approach by using a gel depot loaded natural bacteriophages and a natural bio compound encapsulated with surface engineering nanoparticles. This project intends to propose a novel and alternative approach to avoid the usual severe side-effects affected by the systemic administration of the anticancer pharmaceuticals (e.g., intravenous injections or oral). So, the transdermal drug delivery system is proposed as alternatives that offer promising strategies for the treatment of skin tumours. Melanoma is a skin cancer which can become metastatic, drug-refractory, and lethal if managed late or inappropriately. Besides these already complicated conditions, it is largely known how the depletion of the immunological defence system of the cancer patient can induce infections by opportunist microbial pathogens such as bacteria and fungi. Pathogenic microorganisms with cancers have been reported frequently associated with chronic inflammation in skin malignancies, which can promote skin carcinogenesis inducing the ulceration of cutaneous lesions, and last but not list increasing patient mortality.
The GELNANODEP system provides a depot based on a thermosensitive biodegradable and biocompatible triblock copolymer carrying: (I) surface engineered nanoparticles to specific target alpha 2-beta-3 integrin expressed on tumour cells and selective release sulforaphane which is a natural dietary isothiocyanate mostly characterized by its potent anticancer activity, and (II) naturally bacteriophages inducing the death of pathogenic bacteria.
This proposal will be pursued by a highly interdisciplinary skills, composed of pharmaceutics, polymer chemistry, biology, molecular biology, oncology, clinicals and microbiology.

Status

SIGNED

Call topic

MSCA-IF-2020

Update Date

28-04-2024
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Horizon 2020
H2020-EU.1. EXCELLENT SCIENCE
H2020-EU.1.3. EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions (MSCA)
H2020-EU.1.3.2. Nurturing excellence by means of cross-border and cross-sector mobility
H2020-MSCA-IF-2020
MSCA-IF-2020 Individual Fellowships