Summary
The aim of FISHODOR is to establish the identity of neural network components of the recently discovered tilapia
reproductive pheromone. It will identify pheromone olfactory receptor(s) and their intracellular transduction pathways thereby
increasing our understanding of olfactory perception and signal integration of fish pheromones. The project will determine
the neuronal cell type (i.e. ciliated, microvillous or crypt-type olfactory receptor neurons) detecting the pheromone, it will
establish the transduction pathways (i.e. AC/cAMP or PLC/IP3) involved in its olfactory detection and will identify the
olfactory receptor(s) that binds the pheromone. If enough time is available it will attempt to map the neuronal network
involved in the neuroendocrine response. The combination of electrophysiology, transcriptomics and molecular biology will
bring high degree of novelty to explain the mechanism of action of olfactory receptor and neuronal signal integration.
reproductive pheromone. It will identify pheromone olfactory receptor(s) and their intracellular transduction pathways thereby
increasing our understanding of olfactory perception and signal integration of fish pheromones. The project will determine
the neuronal cell type (i.e. ciliated, microvillous or crypt-type olfactory receptor neurons) detecting the pheromone, it will
establish the transduction pathways (i.e. AC/cAMP or PLC/IP3) involved in its olfactory detection and will identify the
olfactory receptor(s) that binds the pheromone. If enough time is available it will attempt to map the neuronal network
involved in the neuroendocrine response. The combination of electrophysiology, transcriptomics and molecular biology will
bring high degree of novelty to explain the mechanism of action of olfactory receptor and neuronal signal integration.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/746507 |
| Start date: | 01-06-2017 |
| End date: | 31-05-2019 |
| Total budget - Public funding: | 160 635,60 Euro - 160 635,00 Euro |
Cordis data
Original description
The aim of FISHODOR is to establish the identity of neural network components of the recently discovered tilapiareproductive pheromone. It will identify pheromone olfactory receptor(s) and their intracellular transduction pathways thereby
increasing our understanding of olfactory perception and signal integration of fish pheromones. The project will determine
the neuronal cell type (i.e. ciliated, microvillous or crypt-type olfactory receptor neurons) detecting the pheromone, it will
establish the transduction pathways (i.e. AC/cAMP or PLC/IP3) involved in its olfactory detection and will identify the
olfactory receptor(s) that binds the pheromone. If enough time is available it will attempt to map the neuronal network
involved in the neuroendocrine response. The combination of electrophysiology, transcriptomics and molecular biology will
bring high degree of novelty to explain the mechanism of action of olfactory receptor and neuronal signal integration.
Status
CLOSEDCall topic
MSCA-IF-2016Update Date
28-04-2024
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