Summary
The Wnt cascade is an evolutionary conserved pathway that controls cell proliferation, differentiation and growth. Although mutations to this pathway are commonly associated with certain cancers (e.g. colorectal/breast cancer), other mechanisms that control Wnt activity, e.g. its intracellular trafficking regulation, has not received significant attention in the past. The objective of this fellowship is to use my existing knowledge of cell biology to map the trafficking routes that Wnt components take in normal cells, and to test if these routes are altered in cancers to sustain their proliferative capacity. This project will combine bioinformatic analysis to find lead candidates to further investigate in the model organism Drosophila melanogaster. By generating novel fly strains and using high-resolution imaging, I aim to advance our understanding on how Wnt components are trafficked in vivo.
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| Web resources: | https://cordis.europa.eu/project/id/894568 |
| Start date: | 01-09-2021 |
| End date: | 31-08-2023 |
| Total budget - Public funding: | 162 806,40 Euro - 162 806,00 Euro |
Cordis data
Original description
The Wnt cascade is an evolutionary conserved pathway that controls cell proliferation, differentiation and growth. Although mutations to this pathway are commonly associated with certain cancers (e.g. colorectal/breast cancer), other mechanisms that control Wnt activity, e.g. its intracellular trafficking regulation, has not received significant attention in the past. The objective of this fellowship is to use my existing knowledge of cell biology to map the trafficking routes that Wnt components take in normal cells, and to test if these routes are altered in cancers to sustain their proliferative capacity. This project will combine bioinformatic analysis to find lead candidates to further investigate in the model organism Drosophila melanogaster. By generating novel fly strains and using high-resolution imaging, I aim to advance our understanding on how Wnt components are trafficked in vivo.Status
SIGNEDCall topic
MSCA-IF-2019Update Date
28-04-2024
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