Summary
The CLATHROPROBES project is devoted to the design and development of novel, highly efficient chiroptical, luminescent, IR, NMR and EPR probes for sensing and structural studies of biomolecules based on cage metal complexes (clathrochelates and lacunar complexes of spatial tris-diiminate ligands with encapsulated 3d-metal ion) as molecular reporters.
For successful design and synthesis of cage metal complexes (WP1), their complete structural and spectroscopic characterization (WP2), studies of their interactions with biomolecules and reporting properties, and their cytotoxicity and bioactivity in model systems (WP3), the project brings together researchers from four academic institutions and two industrial companies, representing six countries (PL, DE, UA, RO and AU; RU - participation till April 8th, 2022). The participants will contribute to the project with different, highly specific, yet complementary expertise, namely in chemical synthesis of clathrochelate complexes (PBMR and FAU; INEOS RAS participation till April 8th, 2022), identification and structural studies of compounds and materials (PBMR, FAU, UWR, UNIVIE, and SPS; INEOS RAS - participation till April 8th, 2022), characterization of interactions between ligands/clathrochelates/materials and biomolecules by CD, UV-VIS, fluorescence ITC, IR, NMR methodology (UWR, FAU, PBMR, UNIVIE, SPS), and biological studies (FAU).
Joint efforts of participants of this multidisciplinary project will provide - the transfer of knowledge between scientists of different research areas, sectors and countries that will enhance level of their professional scientific/technical expertise, -training of young researchers, very important for their further scientific success or industrial career, - enhancement of research activity and network of participating Institutions, - new long-term collaborations between the partners, - increase of academia-industry interactions, so valuable for innovative ideas and discoveries, and pair scientific excellence with social awareness and understanding of current tasks and problems of science.
For successful design and synthesis of cage metal complexes (WP1), their complete structural and spectroscopic characterization (WP2), studies of their interactions with biomolecules and reporting properties, and their cytotoxicity and bioactivity in model systems (WP3), the project brings together researchers from four academic institutions and two industrial companies, representing six countries (PL, DE, UA, RO and AU; RU - participation till April 8th, 2022). The participants will contribute to the project with different, highly specific, yet complementary expertise, namely in chemical synthesis of clathrochelate complexes (PBMR and FAU; INEOS RAS participation till April 8th, 2022), identification and structural studies of compounds and materials (PBMR, FAU, UWR, UNIVIE, and SPS; INEOS RAS - participation till April 8th, 2022), characterization of interactions between ligands/clathrochelates/materials and biomolecules by CD, UV-VIS, fluorescence ITC, IR, NMR methodology (UWR, FAU, PBMR, UNIVIE, SPS), and biological studies (FAU).
Joint efforts of participants of this multidisciplinary project will provide - the transfer of knowledge between scientists of different research areas, sectors and countries that will enhance level of their professional scientific/technical expertise, -training of young researchers, very important for their further scientific success or industrial career, - enhancement of research activity and network of participating Institutions, - new long-term collaborations between the partners, - increase of academia-industry interactions, so valuable for innovative ideas and discoveries, and pair scientific excellence with social awareness and understanding of current tasks and problems of science.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/778245 |
| Start date: | 01-01-2018 |
| End date: | 31-12-2023 |
| Total budget - Public funding: | 855 000,00 Euro - 796 500,00 Euro |
Cordis data
Original description
The CLATHROPROBES project is devoted to the design and development of novel, highly efficient chiroptical, luminescent, IR, NMR and EPR probes for sensing and structural studies of biomolecules based on cage metal complexes (clathrochelates and lacunar complexes of spatial tris-diiminate ligands with encapsulated 3d-metal ion) as molecular reporters.For successful design and synthesis of cage metal complexes (WP1), their complete structural and spectroscopic characterization (WP2), studies of their interactions with biomolecules and reporting properties, and their cytotoxicity and bioactivity in model systems (WP3), the project brings together researchers from four academic institutions and two industrial companies, representing six countries (PL, DE, UA, RO and AU; RU - participation till April 8th, 2022). The participants will contribute to the project with different, highly specific, yet complementary expertise, namely in chemical synthesis of clathrochelate complexes (PBMR and FAU; INEOS RAS participation till April 8th, 2022), identification and structural studies of compounds and materials (PBMR, FAU, UWR, UNIVIE, and SPS; INEOS RAS - participation till April 8th, 2022), characterization of interactions between ligands/clathrochelates/materials and biomolecules by CD, UV-VIS, fluorescence ITC, IR, NMR methodology (UWR, FAU, PBMR, UNIVIE, SPS), and biological studies (FAU).
Joint efforts of participants of this multidisciplinary project will provide - the transfer of knowledge between scientists of different research areas, sectors and countries that will enhance level of their professional scientific/technical expertise, -training of young researchers, very important for their further scientific success or industrial career, - enhancement of research activity and network of participating Institutions, - new long-term collaborations between the partners, - increase of academia-industry interactions, so valuable for innovative ideas and discoveries, and pair scientific excellence with social awareness and understanding of current tasks and problems of science.
Status
SIGNEDCall topic
MSCA-RISE-2017Update Date
28-04-2024
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Organisations
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| UNIWERSYTET WROCLAWSKI (Coördinator)
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| A.N. NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS OF RUSSIAN ACADEMY OF SCIENCES
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| FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN NURNBERG
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| INNOVATION DEVELOPMENT CENTER ABN LLC
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| SARA PHARM SOLUTIONS SRL
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| SRL POLIVALENT-95
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| SUBSIDIARY COMPANY PRINCETON BIOMOLECULAR RESEARCH LABS
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| UNIVERSITAT WIEN