FARAON | De novo Synthesis of Fluoroarenes and Fluoro(hetero)arenes

Summary
Historically, one of the biggest challenges in synthetic organic chemistry has always been to synthesize fluoroarenes (Ar-F) and fluoroheteroarenes (Het-F) from cheap, readily available starting materials, as fluorination has always concerned synthetic chemists due to either undesirable safety of reagents, low selectivities or poor reactivities. Since fluoroaryl- (Ar-F) and fluoroheteroaryl- (Het-F) are the most common fluorinated motives among pharmaceuticals development of a completely novel synthetic strategy would be of great importance to the research community. De novo construction of fluorobenzene using C1F1 synthons is an unprecedented process. We foresee that little explored monofluorinated ortoformates (RO)3CF (FOFs) could be a synthetic equivalent to access C1F1 synthon for annulation reactions.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/101180677
Start date: 01-04-2025
End date: 31-03-2027
Total budget - Public funding: - 162 499,00 Euro
Cordis data

Original description

Historically, one of the biggest challenges in synthetic organic chemistry has always been to synthesize fluoroarenes (Ar-F) and fluoroheteroarenes (Het-F) from cheap, readily available starting materials, as fluorination has always concerned synthetic chemists due to either undesirable safety of reagents, low selectivities or poor reactivities. Since fluoroaryl- (Ar-F) and fluoroheteroaryl- (Het-F) are the most common fluorinated motives among pharmaceuticals development of a completely novel synthetic strategy would be of great importance to the research community. De novo construction of fluorobenzene using C1F1 synthons is an unprecedented process. We foresee that little explored monofluorinated ortoformates (RO)3CF (FOFs) could be a synthetic equivalent to access C1F1 synthon for annulation reactions.

Status

SIGNED

Call topic

HORIZON-WIDERA-2023-TALENTS-02-01

Update Date

06-11-2024
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Horizon Europe
HORIZON.4 Widening Participation and Strengthening the European Research Area
HORIZON.4.1 Widening participation and spreading excellence
HORIZON.4.1.0 Cross-cutting call topics
HORIZON-WIDERA-2023-TALENTS-02
HORIZON-WIDERA-2023-TALENTS-02-01 ERA Fellowships