Summary
Malaria and Visceral Leishmaniasis (VL) are prevalent parasitic diseases presenting substantial healthcare challenges in tropical and subtropical endemic regions. They share similar geographical distributions, increasing susceptibility during co-infections. Utilizing my multidisciplinary expertise in molecular and cellular biology and parasitology, this research proposal aims to establish a novel murine co-infection model to elucidate the cellular and immunological events during concomitant infection with Plasmodium and Leishmania parasites. Unlike previous studies, we seek to evaluate how Plasmodium affects VL pathology and how Leishmania impacts malaria, providing insights into the disease progression dynamics. Furthermore, we will delineate the immunological responses in single- and co-infected mice, shedding light on host immunity in co-infections. To generate a robust and reproducible murine co-infection model, we will optimize infection parameters, including inoculation routes and parasite doses. The co-infection timing will also be systematically manipulated to discern its impact on disease outcomes. This endeavor holds significant potential to advance our understanding of co-infection biology and contribute significantly to the development of clinical management strategies and therapeutic interventions tailored for co-infections in endemic regions. The host institution’s state-of-the-art facilities and the host laboratory’s extensive experience in investigating co-infections involving Plasmodium and other pathogens ensure an ideal environment for achieving the goals. Ultimately, this project will enable me to become proficient in the field of co-infection biology, encompassing all phases of malaria, including liver, blood, and insect stages. Overall, the research proposal leverages a carefully controlled murine model to illuminate the intricate dynamics of co-infections, contributing to improved healthcare outcomes in regions where these diseases prevail.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101180570 |
| Start date: | 01-06-2024 |
| End date: | 31-05-2026 |
| Total budget - Public funding: | - 156 778,00 Euro |
Cordis data
Original description
Malaria and Visceral Leishmaniasis (VL) are prevalent parasitic diseases presenting substantial healthcare challenges in tropical and subtropical endemic regions. They share similar geographical distributions, increasing susceptibility during co-infections. Utilizing my multidisciplinary expertise in molecular and cellular biology and parasitology, this research proposal aims to establish a novel murine co-infection model to elucidate the cellular and immunological events during concomitant infection with Plasmodium and Leishmania parasites. Unlike previous studies, we seek to evaluate how Plasmodium affects VL pathology and how Leishmania impacts malaria, providing insights into the disease progression dynamics. Furthermore, we will delineate the immunological responses in single- and co-infected mice, shedding light on host immunity in co-infections. To generate a robust and reproducible murine co-infection model, we will optimize infection parameters, including inoculation routes and parasite doses. The co-infection timing will also be systematically manipulated to discern its impact on disease outcomes. This endeavor holds significant potential to advance our understanding of co-infection biology and contribute significantly to the development of clinical management strategies and therapeutic interventions tailored for co-infections in endemic regions. The host institution’s state-of-the-art facilities and the host laboratory’s extensive experience in investigating co-infections involving Plasmodium and other pathogens ensure an ideal environment for achieving the goals. Ultimately, this project will enable me to become proficient in the field of co-infection biology, encompassing all phases of malaria, including liver, blood, and insect stages. Overall, the research proposal leverages a carefully controlled murine model to illuminate the intricate dynamics of co-infections, contributing to improved healthcare outcomes in regions where these diseases prevail.Status
SIGNEDCall topic
HORIZON-WIDERA-2023-TALENTS-02-01Update Date
23-11-2024
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