Summary
Bone tissue engineering has been considered a viable solution Bone tissue engineering has been considered a viable solution for clinical restoration and recovery of defected bone tissue caused by injuries, skeletal dysfunction, and cancer. But current approaches are limited in developing cellular disease models to screen the target genes in tumour relapsing, which enables finding suitable preclinical strategies (animal model). The project will use 3D bioprinting to create an external field driving biosensor-impregnated 3D construct as a potential therapeutic platform for screening bone tumour behaviours and multidisciplinary approaches to bone defect recovery. Hence, the main objective is to determine if the formulation of chiro-magnetic nano-assembly incorporated electro-conductive hydrogel will be able to mimic the in vivo disease model to identify the target of expression in the osteosarcoma model, which will enable the finding of an effective therapeutic strategy for osteosarcoma treatment with gender diversity. The project will focus on the multidisciplinary approach (material science, biochemistry, and cell biology) in the formulation of the multifunctional 3D bioprinting hydrogel (visible light based photo-cross-linkable). The 3D construct will have tunable physical properties such as mechanical stability, chiro-magnetic, etc in determining all stages of cellular behaviour; magnetothermal activity in killing tumour cells; and electro-stimulation mediated osteointegration in tissue regeneration. The project will include the transfer of the candidate’s knowledge to the host and acquiring extensive training from UAveiro on advanced tools and techniques as a part of the career development plan. The results will have a potential impact on humankind and patients from all socio-economical levels, and they are in line with the EU mission to have a significant economic impact on the sustainability of public healthcare care for low-to medium-earning patients' families.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101180630 |
| Start date: | 01-03-2025 |
| End date: | 28-02-2027 |
| Total budget - Public funding: | - 172 618,00 Euro |
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Original description
Bone tissue engineering has been considered a viable solution Bone tissue engineering has been considered a viable solution for clinical restoration and recovery of defected bone tissue caused by injuries, skeletal dysfunction, and cancer. But current approaches are limited in developing cellular disease models to screen the target genes in tumour relapsing, which enables finding suitable preclinical strategies (animal model). The project will use 3D bioprinting to create an external field driving biosensor-impregnated 3D construct as a potential therapeutic platform for screening bone tumour behaviours and multidisciplinary approaches to bone defect recovery. Hence, the main objective is to determine if the formulation of chiro-magnetic nano-assembly incorporated electro-conductive hydrogel will be able to mimic the in vivo disease model to identify the target of expression in the osteosarcoma model, which will enable the finding of an effective therapeutic strategy for osteosarcoma treatment with gender diversity. The project will focus on the multidisciplinary approach (material science, biochemistry, and cell biology) in the formulation of the multifunctional 3D bioprinting hydrogel (visible light based photo-cross-linkable). The 3D construct will have tunable physical properties such as mechanical stability, chiro-magnetic, etc in determining all stages of cellular behaviour; magnetothermal activity in killing tumour cells; and electro-stimulation mediated osteointegration in tissue regeneration. The project will include the transfer of the candidate’s knowledge to the host and acquiring extensive training from UAveiro on advanced tools and techniques as a part of the career development plan. The results will have a potential impact on humankind and patients from all socio-economical levels, and they are in line with the EU mission to have a significant economic impact on the sustainability of public healthcare care for low-to medium-earning patients' families.Status
SIGNEDCall topic
HORIZON-WIDERA-2023-TALENTS-02-01Update Date
06-11-2024
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