Summary
BIOCOCOMER will pursue three general objectives, (Research&Innovation, Training, and International Collaboration) that will be achieved through the development of new skills and products and exchange of multidisciplinary and complementary knowledge and competences within the international Partners from Italy, Australia, Portugal, Spain, Cuba, Switzerland, Germany and South Korea.
Research and Innovation Objectives:
Objective 1 Engineering and Characterising biomolecular functional condensates and coacervates
Objective 2 Understanding the behavior of the bioactive coacervates in cellular environments
Objective 3 Application of coacervates in gene editing of recalcitrant plants
Towards innovative tools for gene delivery in organisms, BIOCOCOMER is focused on the design and engineering of innovative biomolecular condensates/coacervates using peptides, proteins, polysaccharide and nucleic acids, as innovative tools for gene delivery in mammalian cells and plants. Through a combination of computer-based theoretical design and experimental and characterization approaches BIOCOCOMER is expected to generate a library of well-defined condensates and coacervates by programmed co-assembly and phase separation of mixtures of biomacromolecules, i.e polysaccharide-protein, polysaccharide-polyphenols, peptide-peptide, nucleic acid-protein. The condensates and coacervates will be engineered to readily recruit RNA and DNA molecules during phase separation in aqueous solution and to be stimuli responsive to enable transfection of mammalian cells and plants.
Scientific Impact: BIOCOCOMER will ultimately result in significant scientific breakthroughs towards innovative universal transfection tools with widespread biomedical and biotechnological applications. We intend to explore the potential of the developed platforms with the long-term aim of boosting the translational pathway of research in medicine and agriculture.
Research and Innovation Objectives:
Objective 1 Engineering and Characterising biomolecular functional condensates and coacervates
Objective 2 Understanding the behavior of the bioactive coacervates in cellular environments
Objective 3 Application of coacervates in gene editing of recalcitrant plants
Towards innovative tools for gene delivery in organisms, BIOCOCOMER is focused on the design and engineering of innovative biomolecular condensates/coacervates using peptides, proteins, polysaccharide and nucleic acids, as innovative tools for gene delivery in mammalian cells and plants. Through a combination of computer-based theoretical design and experimental and characterization approaches BIOCOCOMER is expected to generate a library of well-defined condensates and coacervates by programmed co-assembly and phase separation of mixtures of biomacromolecules, i.e polysaccharide-protein, polysaccharide-polyphenols, peptide-peptide, nucleic acid-protein. The condensates and coacervates will be engineered to readily recruit RNA and DNA molecules during phase separation in aqueous solution and to be stimuli responsive to enable transfection of mammalian cells and plants.
Scientific Impact: BIOCOCOMER will ultimately result in significant scientific breakthroughs towards innovative universal transfection tools with widespread biomedical and biotechnological applications. We intend to explore the potential of the developed platforms with the long-term aim of boosting the translational pathway of research in medicine and agriculture.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101182806 |
| Start date: | 01-01-2025 |
| End date: | 31-12-2028 |
| Total budget - Public funding: | - 1 154 600,00 Euro |
Cordis data
Original description
BIOCOCOMER will pursue three general objectives, (Research&Innovation, Training, and International Collaboration) that will be achieved through the development of new skills and products and exchange of multidisciplinary and complementary knowledge and competences within the international Partners from Italy, Australia, Portugal, Spain, Cuba, Switzerland, Germany and South Korea.Research and Innovation Objectives:
Objective 1 Engineering and Characterising biomolecular functional condensates and coacervates
Objective 2 Understanding the behavior of the bioactive coacervates in cellular environments
Objective 3 Application of coacervates in gene editing of recalcitrant plants
Towards innovative tools for gene delivery in organisms, BIOCOCOMER is focused on the design and engineering of innovative biomolecular condensates/coacervates using peptides, proteins, polysaccharide and nucleic acids, as innovative tools for gene delivery in mammalian cells and plants. Through a combination of computer-based theoretical design and experimental and characterization approaches BIOCOCOMER is expected to generate a library of well-defined condensates and coacervates by programmed co-assembly and phase separation of mixtures of biomacromolecules, i.e polysaccharide-protein, polysaccharide-polyphenols, peptide-peptide, nucleic acid-protein. The condensates and coacervates will be engineered to readily recruit RNA and DNA molecules during phase separation in aqueous solution and to be stimuli responsive to enable transfection of mammalian cells and plants.
Scientific Impact: BIOCOCOMER will ultimately result in significant scientific breakthroughs towards innovative universal transfection tools with widespread biomedical and biotechnological applications. We intend to explore the potential of the developed platforms with the long-term aim of boosting the translational pathway of research in medicine and agriculture.
Status
SIGNEDCall topic
HORIZON-MSCA-2023-SE-01-01Update Date
22-11-2024
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Organisations
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| UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA (Coördinator)
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| CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
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| Gyeongsang National University
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| INNO-SOL SOCIETA A RESPONSABILITA LIMITATA START-UP INNOVATIVA
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| LABORATORIO IBERICO INTERNACIONAL DE NANOTECNOLOGIA (LIN INL)
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| LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV
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| ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY*RMIT UNIVERSITY
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| UNIVERSIDAD DE VIGO (UVIGO) - University of Vigo
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| UNIVERSITA DEGLI STUDI DI PADOVA - University of Padova
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| UNIVERSITE DE FRIBOURG
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| UNIVERSITY OF MELBOURNE