Summary
Methane is one of the most abundant, underutilized carbon-based chemical feedstocks on the planet. Moreover, the simplest alkane is one of the most potent greenhouse gases in the atmosphere due to which United Nations has lunched the global methane initiative for achieving a 30% reduction in its emission by 2030. The current methodologies for the utilization and disposal of methane gas suffer due to being cost intensive and non-sustainable. As a result, there is an urgent need to develop protocols, which allow the transformation of this greenhouse gas into valuable products in a profitable manner.
On the other hand, the selective substitution of C-H bonds in drug candidates to C-Me bonds have often led to an average 100-fold increase in their biological activity (Magic Methyl Effect). As a result, protocols which allow the selective incorporation of methyl groups into organic substrates have gained wide attention.
The proposed project aims at developing efficient catalytic processes that allow direct methane functionalization by using it as a methylating reagent in a variety of C-Me bond forming reactions through dual transition metal photoredox catalysis. New pathways for the direct use of methane in reactions such as cross-couplings, C-H methylations and cascade cyclizations will be developed based on this novel bimetallic photocatalytic strategy.
It is envisioned that the proposed research will open new avenues for the utilization of methane as feedstock for the synthesis of drugs and biorelevant molecules, thus contributing to the reduction in the emissions of this gas and helping to reach UN’s global methane initiative and to EU’s European Green Deal objective of achieving zero net greenhouse gas emission by 2050.
On the other hand, the selective substitution of C-H bonds in drug candidates to C-Me bonds have often led to an average 100-fold increase in their biological activity (Magic Methyl Effect). As a result, protocols which allow the selective incorporation of methyl groups into organic substrates have gained wide attention.
The proposed project aims at developing efficient catalytic processes that allow direct methane functionalization by using it as a methylating reagent in a variety of C-Me bond forming reactions through dual transition metal photoredox catalysis. New pathways for the direct use of methane in reactions such as cross-couplings, C-H methylations and cascade cyclizations will be developed based on this novel bimetallic photocatalytic strategy.
It is envisioned that the proposed research will open new avenues for the utilization of methane as feedstock for the synthesis of drugs and biorelevant molecules, thus contributing to the reduction in the emissions of this gas and helping to reach UN’s global methane initiative and to EU’s European Green Deal objective of achieving zero net greenhouse gas emission by 2050.
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| Web resources: | https://cordis.europa.eu/project/id/101150274 |
| Start date: | 01-08-2024 |
| End date: | 31-07-2026 |
| Total budget - Public funding: | - 165 312,00 Euro |
Cordis data
Original description
Methane is one of the most abundant, underutilized carbon-based chemical feedstocks on the planet. Moreover, the simplest alkane is one of the most potent greenhouse gases in the atmosphere due to which United Nations has lunched the global methane initiative for achieving a 30% reduction in its emission by 2030. The current methodologies for the utilization and disposal of methane gas suffer due to being cost intensive and non-sustainable. As a result, there is an urgent need to develop protocols, which allow the transformation of this greenhouse gas into valuable products in a profitable manner.On the other hand, the selective substitution of C-H bonds in drug candidates to C-Me bonds have often led to an average 100-fold increase in their biological activity (Magic Methyl Effect). As a result, protocols which allow the selective incorporation of methyl groups into organic substrates have gained wide attention.
The proposed project aims at developing efficient catalytic processes that allow direct methane functionalization by using it as a methylating reagent in a variety of C-Me bond forming reactions through dual transition metal photoredox catalysis. New pathways for the direct use of methane in reactions such as cross-couplings, C-H methylations and cascade cyclizations will be developed based on this novel bimetallic photocatalytic strategy.
It is envisioned that the proposed research will open new avenues for the utilization of methane as feedstock for the synthesis of drugs and biorelevant molecules, thus contributing to the reduction in the emissions of this gas and helping to reach UN’s global methane initiative and to EU’s European Green Deal objective of achieving zero net greenhouse gas emission by 2050.
Status
SIGNEDCall topic
HORIZON-MSCA-2023-PF-01-01Update Date
25-11-2024
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