Summary
Diabetes is a chronic metabolic syndrome with millions of people affected globally, caused by impaired glucose metabolism due to insufficient pancreatic insulin release or the development of insulin resistance. To control the glycaemic load in the diabetic patient, insulin needs to be administered by parenteral injection which causes patient compliance issues. Oral administration of insulin is the preferred route but there is no oral insulin on the market because of the hurdles it faces in the gastro-intestinal tract. Oral administration is the preferred route but until now there is no oral insulin in the market because of the hurdle (gastric pH and enzymatic degradation, low permeability) it faces in the gastrointestinal tract. Therefore, there is an unmet need for oral insulin development. To solve these problems, we will use microneedle technology for development of oral insulin delivery (Micro-Insulin). Oral administration of Micro-insulin will be investigated at the level of physicochemical characterization, preliminary safety assessment in in vitro and ex vivo models, and pharmacokinetics and efficacy in in vivo rodent models. High insulin intestinal absorption will be expected from the polymeric needle microcapsule via its piercing mechanism with controlled and localised release of insulin, which will be facilitated by a polymer matrix and the permeating-enhancing cationic cyclodextrin polymer. The objective of the project is aligned with the EU’s Horizon 2020 Programme focus area - Health, Demographic Change and Wellbeing and UN Sustainable Development Goal - Good Health and Well-Being. The Global Marie Curie Fellowship research will be conducted in partnership with the outgoing phase at a renowned institution from a third countries and incoming phase at EU country. The team is well equipped with skill and infrastructure required for the project. This will help bring advanced skills to EU countries and will have a significant impact on the fellow's career.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101153855 |
| Start date: | 01-01-2025 |
| End date: | 31-12-2027 |
| Total budget - Public funding: | - 302 331,00 Euro |
Cordis data
Original description
Diabetes is a chronic metabolic syndrome with millions of people affected globally, caused by impaired glucose metabolism due to insufficient pancreatic insulin release or the development of insulin resistance. To control the glycaemic load in the diabetic patient, insulin needs to be administered by parenteral injection which causes patient compliance issues. Oral administration of insulin is the preferred route but there is no oral insulin on the market because of the hurdles it faces in the gastro-intestinal tract. Oral administration is the preferred route but until now there is no oral insulin in the market because of the hurdle (gastric pH and enzymatic degradation, low permeability) it faces in the gastrointestinal tract. Therefore, there is an unmet need for oral insulin development. To solve these problems, we will use microneedle technology for development of oral insulin delivery (Micro-Insulin). Oral administration of Micro-insulin will be investigated at the level of physicochemical characterization, preliminary safety assessment in in vitro and ex vivo models, and pharmacokinetics and efficacy in in vivo rodent models. High insulin intestinal absorption will be expected from the polymeric needle microcapsule via its piercing mechanism with controlled and localised release of insulin, which will be facilitated by a polymer matrix and the permeating-enhancing cationic cyclodextrin polymer. The objective of the project is aligned with the EU’s Horizon 2020 Programme focus area - Health, Demographic Change and Wellbeing and UN Sustainable Development Goal - Good Health and Well-Being. The Global Marie Curie Fellowship research will be conducted in partnership with the outgoing phase at a renowned institution from a third countries and incoming phase at EU country. The team is well equipped with skill and infrastructure required for the project. This will help bring advanced skills to EU countries and will have a significant impact on the fellow's career.Status
SIGNEDCall topic
HORIZON-MSCA-2023-PF-01-01Update Date
18-09-2024
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