Summary
In recent years, the importance of biomedical implants has surged in addressing various medical conditions, including bone fractures, heart ailments, and other healthcare challenges. As healthcare complexities continue to escalate, there is a growing demand for biodegradable implants. Pioneering research in medical science is driving the scientific community toward the latest generation of biomedical implants, which closely mimic natural bone and tissues, greatly enhancing their biocompatibility. For instance, temporary medical implants are now based on biodegradable metals like magnesium (Mg), zinc (Zn), and iron (Fe), offering promising potential. Mg alloys, in particular, have a long and illustrious history, especially in bone-support applications. Their elastic modulus closely matches that of natural cortical bone, thereby reducing the occurrence of stress-shielding effects. Furthermore, the body's established pathways for excreting excess Mg via urine make Mg-based alloys ideal candidates for resorbable implants. It is anticipated that Mg-based implants will degrade within a suitable timeframe within the human body.
However, there are challenges associated with metallic implants. Firstly, achieving a uniform and predictable degradation rate of implant within the human body. Complete dissolution of the implant after fulfilling its function can provide substantial benefits to the patient by eliminating the risks and costs associated with secondary surgeries and complications, such as hypersensitivity. The second major challenge lies in using biologically safe, low-alloyed magnesium, which, unfortunately, results in high corrosion rates and the formation of hydrogen bubbles that can hinder the healing process.
To address these challenges, we propose the development of a novel methodology for producing Mg-based alloys suitable for biodegradable, resorbable implant applications, offering excellent performance.
However, there are challenges associated with metallic implants. Firstly, achieving a uniform and predictable degradation rate of implant within the human body. Complete dissolution of the implant after fulfilling its function can provide substantial benefits to the patient by eliminating the risks and costs associated with secondary surgeries and complications, such as hypersensitivity. The second major challenge lies in using biologically safe, low-alloyed magnesium, which, unfortunately, results in high corrosion rates and the formation of hydrogen bubbles that can hinder the healing process.
To address these challenges, we propose the development of a novel methodology for producing Mg-based alloys suitable for biodegradable, resorbable implant applications, offering excellent performance.
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| Web resources: | https://cordis.europa.eu/project/id/101154423 |
| Start date: | 16-09-2024 |
| End date: | 15-09-2026 |
| Total budget - Public funding: | - 166 278,00 Euro |
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Original description
In recent years, the importance of biomedical implants has surged in addressing various medical conditions, including bone fractures, heart ailments, and other healthcare challenges. As healthcare complexities continue to escalate, there is a growing demand for biodegradable implants. Pioneering research in medical science is driving the scientific community toward the latest generation of biomedical implants, which closely mimic natural bone and tissues, greatly enhancing their biocompatibility. For instance, temporary medical implants are now based on biodegradable metals like magnesium (Mg), zinc (Zn), and iron (Fe), offering promising potential. Mg alloys, in particular, have a long and illustrious history, especially in bone-support applications. Their elastic modulus closely matches that of natural cortical bone, thereby reducing the occurrence of stress-shielding effects. Furthermore, the body's established pathways for excreting excess Mg via urine make Mg-based alloys ideal candidates for resorbable implants. It is anticipated that Mg-based implants will degrade within a suitable timeframe within the human body.However, there are challenges associated with metallic implants. Firstly, achieving a uniform and predictable degradation rate of implant within the human body. Complete dissolution of the implant after fulfilling its function can provide substantial benefits to the patient by eliminating the risks and costs associated with secondary surgeries and complications, such as hypersensitivity. The second major challenge lies in using biologically safe, low-alloyed magnesium, which, unfortunately, results in high corrosion rates and the formation of hydrogen bubbles that can hinder the healing process.
To address these challenges, we propose the development of a novel methodology for producing Mg-based alloys suitable for biodegradable, resorbable implant applications, offering excellent performance.
Status
SIGNEDCall topic
HORIZON-MSCA-2023-PF-01-01Update Date
03-10-2024
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