Summary
Ischaemic heart disease (IHD) is the leading cause of mortality in Europe with about 1.8 million reported deaths per year in
Europe alone. A serious consequence of IHD can be stopping blood flow to the heart causing a Myocardial Infarction (MI). In
the most severe cases this has a mortality rate between 6% and 14%. Clinical guidelines recommend immediate restoration
of the blood flow via reperfusion therapy. However, this procedure results in high acute mortality (10%) and a significant
incidence of congestive heart failure (12%) due to inflammation and ensuing cell death of the myocardial tissues. Current
treatments do not provide a cardio-protective effect to mitigate this. Several potential therapies have emerged as promising
cardio-protective therapeutic strategies for severe cases of MI, but up to date these have all failed to prove efficacy in later
stages of human clinical trials.
ResoTher Pharma ApS is a biotechnology company focused on developing a new class of therapeutics targeting the
resolution of inflammatory responses. The company´s first drug candidate is a novel peptide with unique cardio-protective
capabilities. Results from animal models reveal promising tissue-protective effects - decreases in myocardial damage related
to the reperfusion injury (52%) and an overall improvement of the survival rate after an MI (up to 400%). The clinical
validation of the lead drug will be key to demonstrate safety and efficacy in humans and allow ResoTher to establish itself in
the chronic inflammatory disease market. The present SMEi Phase 1 will be of utmost importance to engage key
stakeholders and prepare the clinical development plan in readiness for implementation during the Innovation Project. The
clinical validation of the lead drug will lead to a significant business opportunity for ResoTher, supporting the company´s
medium term strategic positioning as a unique provider of a new generation of anti-inflammatory drugs.
Europe alone. A serious consequence of IHD can be stopping blood flow to the heart causing a Myocardial Infarction (MI). In
the most severe cases this has a mortality rate between 6% and 14%. Clinical guidelines recommend immediate restoration
of the blood flow via reperfusion therapy. However, this procedure results in high acute mortality (10%) and a significant
incidence of congestive heart failure (12%) due to inflammation and ensuing cell death of the myocardial tissues. Current
treatments do not provide a cardio-protective effect to mitigate this. Several potential therapies have emerged as promising
cardio-protective therapeutic strategies for severe cases of MI, but up to date these have all failed to prove efficacy in later
stages of human clinical trials.
ResoTher Pharma ApS is a biotechnology company focused on developing a new class of therapeutics targeting the
resolution of inflammatory responses. The company´s first drug candidate is a novel peptide with unique cardio-protective
capabilities. Results from animal models reveal promising tissue-protective effects - decreases in myocardial damage related
to the reperfusion injury (52%) and an overall improvement of the survival rate after an MI (up to 400%). The clinical
validation of the lead drug will be key to demonstrate safety and efficacy in humans and allow ResoTher to establish itself in
the chronic inflammatory disease market. The present SMEi Phase 1 will be of utmost importance to engage key
stakeholders and prepare the clinical development plan in readiness for implementation during the Innovation Project. The
clinical validation of the lead drug will lead to a significant business opportunity for ResoTher, supporting the company´s
medium term strategic positioning as a unique provider of a new generation of anti-inflammatory drugs.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/888174 |
| Start date: | 01-11-2019 |
| End date: | 29-02-2020 |
| Total budget - Public funding: | 71 429,00 Euro - 50 000,00 Euro |
Cordis data
Original description
Ischaemic heart disease (IHD) is the leading cause of mortality in Europe with about 1.8 million reported deaths per year inEurope alone. A serious consequence of IHD can be stopping blood flow to the heart causing a Myocardial Infarction (MI). In
the most severe cases this has a mortality rate between 6% and 14%. Clinical guidelines recommend immediate restoration
of the blood flow via reperfusion therapy. However, this procedure results in high acute mortality (10%) and a significant
incidence of congestive heart failure (12%) due to inflammation and ensuing cell death of the myocardial tissues. Current
treatments do not provide a cardio-protective effect to mitigate this. Several potential therapies have emerged as promising
cardio-protective therapeutic strategies for severe cases of MI, but up to date these have all failed to prove efficacy in later
stages of human clinical trials.
ResoTher Pharma ApS is a biotechnology company focused on developing a new class of therapeutics targeting the
resolution of inflammatory responses. The company´s first drug candidate is a novel peptide with unique cardio-protective
capabilities. Results from animal models reveal promising tissue-protective effects - decreases in myocardial damage related
to the reperfusion injury (52%) and an overall improvement of the survival rate after an MI (up to 400%). The clinical
validation of the lead drug will be key to demonstrate safety and efficacy in humans and allow ResoTher to establish itself in
the chronic inflammatory disease market. The present SMEi Phase 1 will be of utmost importance to engage key
stakeholders and prepare the clinical development plan in readiness for implementation during the Innovation Project. The
clinical validation of the lead drug will lead to a significant business opportunity for ResoTher, supporting the company´s
medium term strategic positioning as a unique provider of a new generation of anti-inflammatory drugs.
Status
CLOSEDCall topic
EIC-SMEInst-2018-2020Update Date
27-10-2022
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