GRANROSE | Using a blood cell-based approach to determine gluten responsiveness and to bring a novel, less invasive assay on the market to diagnose celiac disease.

Summary
Microbiome is a Dutch R&D-performing SME developing molecular diagnostic assays based on human biomarkers with one of its focuses to celiac disease diagnostics. We developed a molecular diagnostic assay to screen HLA genotypes that are known to be associated with celiac disease (CD). Up to date, CD is diagnosed by serology (e.g. the presence of auto-antibodies to tissue transglutaminase 2 in the serum) and diagnosis requires further proof by analysis of a duodenal biopsy specimen. The collection of biopsy specimens requires an invasive examination and correct embedding of the tissue is essential for proper analysis of the tissue. This part of CD diagnosis is expensive, elaborate and prone to mistake. Innovation that trustworthy and efficiently can replace biopsy is in high demand. GRANROSE will enable Microbiome to strengthen its position as an innovative biotech SME, developing a novel assay, NeutroScan, for the CD market. GRANROSE will do this through hiring an Innovation Associate (IA).
• The IA will confirm and complete a biomarker panel that plays a role in gluten-related neutrophil function.
• The IA will develop an assay to study neutrophil function in gluten-related disease.
• The IA will perform a technical feasibility study for and investigate the market potential of the NeutroScan, an assay distinguishing gluten-related disease based on neutrophil function.
GRANROSE will not only bring major benefits for Microbiome, but is focused around the training of the Innovation Associate, thereby greatly improving his/her career development.
• Gaining novel technical skills and building an own research line with translational diagnostic applications.
• Gaining innovation and business management skills in a multidisciplinary setting.
• A training program tailored to his/her specific needs and major contribution to personal career development.
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/861910
Start date: 15-10-2019
End date: 14-10-2020
Total budget - Public funding: 130 062,50 Euro - 130 062,00 Euro
Cordis data

Original description

Microbiome is a Dutch R&D-performing SME developing molecular diagnostic assays based on human biomarkers with one of its focuses to celiac disease diagnostics. We developed a molecular diagnostic assay to screen HLA genotypes that are known to be associated with celiac disease (CD). Up to date, CD is diagnosed by serology (e.g. the presence of auto-antibodies to tissue transglutaminase 2 in the serum) and diagnosis requires further proof by analysis of a duodenal biopsy specimen. The collection of biopsy specimens requires an invasive examination and correct embedding of the tissue is essential for proper analysis of the tissue. This part of CD diagnosis is expensive, elaborate and prone to mistake. Innovation that trustworthy and efficiently can replace biopsy is in high demand. GRANROSE will enable Microbiome to strengthen its position as an innovative biotech SME, developing a novel assay, NeutroScan, for the CD market. GRANROSE will do this through hiring an Innovation Associate (IA).
• The IA will confirm and complete a biomarker panel that plays a role in gluten-related neutrophil function.
• The IA will develop an assay to study neutrophil function in gluten-related disease.
• The IA will perform a technical feasibility study for and investigate the market potential of the NeutroScan, an assay distinguishing gluten-related disease based on neutrophil function.
GRANROSE will not only bring major benefits for Microbiome, but is focused around the training of the Innovation Associate, thereby greatly improving his/her career development.
• Gaining novel technical skills and building an own research line with translational diagnostic applications.
• Gaining innovation and business management skills in a multidisciplinary setting.
• A training program tailored to his/her specific needs and major contribution to personal career development.

Status

CLOSED

Call topic

INNOSUP-02-2019-2020

Update Date

27-10-2022
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Horizon 2020
H2020-EU.2. INDUSTRIAL LEADERSHIP
H2020-EU.2.3. INDUSTRIAL LEADERSHIP - Innovation In SMEs
H2020-EU.2.3.2. Specific support
H2020-EU.2.3.2.2. Enhancing the innovation capacity of SMEs
H2020-INNOSUP-2019-02
INNOSUP-02-2019-2020 European SME innovation Associate - pilot