Summary
Environmental stresses trigger metabolic changes that alter the internal carbon/nitrogen (C/N) balance in plants to promote tolerance at the expense of growth. However, the metabolic and genetic components involved in the precise coordination of the nutritional status remain largely unknown. MetaboSignal’s aim is elucidating novel signalling mechanisms governing nutrient balance by using C/N stress conditions as a proxy. This 3-year project proposes the integration of molecular genetics and biological chemistry disciplines to identify signalling functions of intermediate metabolites derived from C and N metabolism and characterize new nutritional sensors of C/N balance. Here, several innovative and powerful methods for chemical distribution mapping, proteomics and transcriptomic analyses are integrated in a convergent workflow with gene functional characterization to be carried out in cutting-edge institutions such as University of California San Diego and Universidad Politécnica de Madrid. Implementation of this multidisciplinary proposal will greatly bolster the fellow´s scientific profile and will uncover novel metabolite-controlled signalling pathways useful for knowledge-based improvements on plant nutrition and crop yield of scientific and societal relevance.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101155560 |
| Start date: | 01-04-2025 |
| End date: | 31-03-2028 |
| Total budget - Public funding: | - 261 380,00 Euro |
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Original description
Environmental stresses trigger metabolic changes that alter the internal carbon/nitrogen (C/N) balance in plants to promote tolerance at the expense of growth. However, the metabolic and genetic components involved in the precise coordination of the nutritional status remain largely unknown. MetaboSignal’s aim is elucidating novel signalling mechanisms governing nutrient balance by using C/N stress conditions as a proxy. This 3-year project proposes the integration of molecular genetics and biological chemistry disciplines to identify signalling functions of intermediate metabolites derived from C and N metabolism and characterize new nutritional sensors of C/N balance. Here, several innovative and powerful methods for chemical distribution mapping, proteomics and transcriptomic analyses are integrated in a convergent workflow with gene functional characterization to be carried out in cutting-edge institutions such as University of California San Diego and Universidad Politécnica de Madrid. Implementation of this multidisciplinary proposal will greatly bolster the fellow´s scientific profile and will uncover novel metabolite-controlled signalling pathways useful for knowledge-based improvements on plant nutrition and crop yield of scientific and societal relevance.Status
SIGNEDCall topic
HORIZON-MSCA-2023-PF-01-01Update Date
20-09-2024
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