Summary
UPOXARENE is an interdisciplinary project combining organic synthesis, biocatalysis, and protein engineering, to realise the elusive epoxidation of arenes in a single step using engineered unspecific peroxygenases (UPOs). The compatibility of UPOs with organic media will be exploited to expand their chemistry beyond the aromatic hydroxylation accessible with cytochrome P450s. The utility of the method will be demonstrated through the preparation of industrially relevant products in continuous chemo-enzymatic cascades, in alignment with the principles set out in the MSCA Green Charter. UPOXARENE will promote biotechnology through the citizen-science initiative Peroxynauts, encouraging students from all backgrounds to pursue careers in the life sciences.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/101151329 |
| Start date: | 01-11-2024 |
| End date: | 31-10-2026 |
| Total budget - Public funding: | - 187 624,00 Euro |
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Original description
UPOXARENE is an interdisciplinary project combining organic synthesis, biocatalysis, and protein engineering, to realise the elusive epoxidation of arenes in a single step using engineered unspecific peroxygenases (UPOs). The compatibility of UPOs with organic media will be exploited to expand their chemistry beyond the aromatic hydroxylation accessible with cytochrome P450s. The utility of the method will be demonstrated through the preparation of industrially relevant products in continuous chemo-enzymatic cascades, in alignment with the principles set out in the MSCA Green Charter. UPOXARENE will promote biotechnology through the citizen-science initiative Peroxynauts, encouraging students from all backgrounds to pursue careers in the life sciences.Status
SIGNEDCall topic
HORIZON-MSCA-2023-PF-01-01Update Date
21-11-2024
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