Summary
This project aims to close the gap to the market for a small molecule AMP activated protein kinase (AMPK) activator,
denoted O304, as a novel first-in-class drug for the treatment of type 2 diabetes (T2D) and associated cardiovascular
complications, including heart failure and peripheral arterial disease.
The number of adults around the world with diabetes quadrupled from 108 million in 1980 to 422 million in 2014. About 90%
of these people have type 2 diabetes — a major cause of kidney failure, blindness, nerve damage, amputations, heart attack
and stroke. It is estimated that only approx. 10 % of T2 diabetics reach the goal of living a complication free life.
Today, patients diagnosed with T2D are recommended a change in lifestyle and the drug Metformin is the first line of
treatment. When Metformin becomes insufficient, a number of add-on treatments are used, including insulin. None of the
existing drugs, however, reduces insulin resistance - a primary cause of obesity-induced T2D.
Betagenon has developed and pre-validated the first candidate AMPK activator drug in T2 diabetics, a key regulator of
energy balance, both on a single cell level and the whole organism level. Phase I clinical data show that O304 reduces
fasting plasma glucose, the hallmark of T2D, in patients with T2D on stable metformin treatment, and increases the rate of
hyperaemic blood in calf muscle in middle aged obese individuals. The project is strategically focused on performing a
Phase IIa proof-of-concept validation of O304. This will enable Betagenon to commercialize the product through outlicensing
to a Phase IIb and Phase III validation partner.
Diabetes is an epidemic that threatens the economies of all EU member states. The project addresses this challenge by
delivering a novel drug treatment regimen to clinicians and their patients. O304 will fill the knowledge gap on the EU level, as
to date no company has been able to pre-validate an efficient small molecule AMPK activator.
denoted O304, as a novel first-in-class drug for the treatment of type 2 diabetes (T2D) and associated cardiovascular
complications, including heart failure and peripheral arterial disease.
The number of adults around the world with diabetes quadrupled from 108 million in 1980 to 422 million in 2014. About 90%
of these people have type 2 diabetes — a major cause of kidney failure, blindness, nerve damage, amputations, heart attack
and stroke. It is estimated that only approx. 10 % of T2 diabetics reach the goal of living a complication free life.
Today, patients diagnosed with T2D are recommended a change in lifestyle and the drug Metformin is the first line of
treatment. When Metformin becomes insufficient, a number of add-on treatments are used, including insulin. None of the
existing drugs, however, reduces insulin resistance - a primary cause of obesity-induced T2D.
Betagenon has developed and pre-validated the first candidate AMPK activator drug in T2 diabetics, a key regulator of
energy balance, both on a single cell level and the whole organism level. Phase I clinical data show that O304 reduces
fasting plasma glucose, the hallmark of T2D, in patients with T2D on stable metformin treatment, and increases the rate of
hyperaemic blood in calf muscle in middle aged obese individuals. The project is strategically focused on performing a
Phase IIa proof-of-concept validation of O304. This will enable Betagenon to commercialize the product through outlicensing
to a Phase IIb and Phase III validation partner.
Diabetes is an epidemic that threatens the economies of all EU member states. The project addresses this challenge by
delivering a novel drug treatment regimen to clinicians and their patients. O304 will fill the knowledge gap on the EU level, as
to date no company has been able to pre-validate an efficient small molecule AMPK activator.
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More information & hyperlinks
| Web resources: | https://cordis.europa.eu/project/id/754268 |
| Start date: | 01-11-2016 |
| End date: | 30-06-2018 |
| Total budget - Public funding: | 2 604 625,00 Euro - 1 823 237,00 Euro |
Cordis data
Original description
This project aims to close the gap to the market for a small molecule AMP activated protein kinase (AMPK) activator,denoted O304, as a novel first-in-class drug for the treatment of type 2 diabetes (T2D) and associated cardiovascular
complications, including heart failure and peripheral arterial disease.
The number of adults around the world with diabetes quadrupled from 108 million in 1980 to 422 million in 2014. About 90%
of these people have type 2 diabetes — a major cause of kidney failure, blindness, nerve damage, amputations, heart attack
and stroke. It is estimated that only approx. 10 % of T2 diabetics reach the goal of living a complication free life.
Today, patients diagnosed with T2D are recommended a change in lifestyle and the drug Metformin is the first line of
treatment. When Metformin becomes insufficient, a number of add-on treatments are used, including insulin. None of the
existing drugs, however, reduces insulin resistance - a primary cause of obesity-induced T2D.
Betagenon has developed and pre-validated the first candidate AMPK activator drug in T2 diabetics, a key regulator of
energy balance, both on a single cell level and the whole organism level. Phase I clinical data show that O304 reduces
fasting plasma glucose, the hallmark of T2D, in patients with T2D on stable metformin treatment, and increases the rate of
hyperaemic blood in calf muscle in middle aged obese individuals. The project is strategically focused on performing a
Phase IIa proof-of-concept validation of O304. This will enable Betagenon to commercialize the product through outlicensing
to a Phase IIb and Phase III validation partner.
Diabetes is an epidemic that threatens the economies of all EU member states. The project addresses this challenge by
delivering a novel drug treatment regimen to clinicians and their patients. O304 will fill the knowledge gap on the EU level, as
to date no company has been able to pre-validate an efficient small molecule AMPK activator.
Status
CLOSEDCall topic
SMEInst-03-2016-2017Update Date
27-10-2022
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H2020-EU.2.1.4. INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology
