Sea4Pain | Development of a novel analgesic for chronic pain from marine-derived compounds

Summary
"The Sea4Pain project will expand and define the development strategy for Sea4Us’s “Drug Discovery and Development Platform” – a platform that applies novel biotechnological approaches to exploit marine derived compounds for the development of novel pharmaceuticals highly relevant for biomedicine. The first lab-based research results have clearly demonstrated the benefits of marine compounds in a series of pathologies, like chronic pain, and the huge potential of its derivate products in the health market. In particular, our innovative breakthroughs will lead to the development of a unique, high efficacy analgesic (ion channel modulator), with reduced toxicity and limited side-effects (Sea4Pain). This extremely innovative approach shows a differentiated mode-of-action (acting directly in the ""pain switch""), that will give rise to a new class of pharmaceutical drugs with no expected adverse effects on the brain (currently being patented). The disruptive compound will modulate specific ion channels in pain-sensing neurons (Kv), for which there is no known modulator, and ease the suffering of one fifth of the World's population who constantly suffer from chronic pain. Sea4Pain will offer alternative treatments for patients suffering from moderate to severe chronic pain. Current drugs in the market (opioid derivatives and others) do alleviate pain but co-inflict important noxious effects (habituation, addiction, loss of drive) and great loss in quality of life. The global pain management drugs and devices market was estimated to be worth $38 billion in 2015 and reach $51 billion in 2022 at a CAGR of 4%. Founded in 2013, Sea4Us has received over 525.000€ in Portuguese and European Research Grants, raised 10.000€ with crowdfunding, and 250.000€ in venture capital, supporting a team of 13 professionals and is focused on developing the Sea4Pain roll-to-market of innovative treatments."
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More information & hyperlinks
Web resources: https://cordis.europa.eu/project/id/815852
Start date: 01-05-2018
End date: 30-09-2018
Total budget - Public funding: 71 429,00 Euro - 50 000,00 Euro
Cordis data

Original description

"The Sea4Pain project will expand and define the development strategy for Sea4Us’s “Drug Discovery and Development Platform” – a platform that applies novel biotechnological approaches to exploit marine derived compounds for the development of novel pharmaceuticals highly relevant for biomedicine. The first lab-based research results have clearly demonstrated the benefits of marine compounds in a series of pathologies, like chronic pain, and the huge potential of its derivate products in the health market. In particular, our innovative breakthroughs will lead to the development of a unique, high efficacy analgesic (ion channel modulator), with reduced toxicity and limited side-effects (Sea4Pain). This extremely innovative approach shows a differentiated mode-of-action (acting directly in the ""pain switch""), that will give rise to a new class of pharmaceutical drugs with no expected adverse effects on the brain (currently being patented). The disruptive compound will modulate specific ion channels in pain-sensing neurons (Kv), for which there is no known modulator, and ease the suffering of one fifth of the World's population who constantly suffer from chronic pain. Sea4Pain will offer alternative treatments for patients suffering from moderate to severe chronic pain. Current drugs in the market (opioid derivatives and others) do alleviate pain but co-inflict important noxious effects (habituation, addiction, loss of drive) and great loss in quality of life. The global pain management drugs and devices market was estimated to be worth $38 billion in 2015 and reach $51 billion in 2022 at a CAGR of 4%. Founded in 2013, Sea4Us has received over 525.000€ in Portuguese and European Research Grants, raised 10.000€ with crowdfunding, and 250.000€ in venture capital, supporting a team of 13 professionals and is focused on developing the Sea4Pain roll-to-market of innovative treatments."

Status

CLOSED

Call topic

EIC-SMEInst-2018-2020

Update Date

27-10-2022
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Horizon 2020
H2020-EU.2. INDUSTRIAL LEADERSHIP
H2020-EU.2.1. INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
H2020-EU.2.1.0. INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Cross-cutting calls
H2020-EIC-SMEInst-2018-2020
H2020-SMEInst-2018-2020-1
H2020-EU.2.3. INDUSTRIAL LEADERSHIP - Innovation In SMEs
H2020-EU.2.3.0. INDUSTRIAL LEADERSHIP - Innovation In SMEs - Cross-cutting calls
H2020-EIC-SMEInst-2018-2020
H2020-SMEInst-2018-2020-1
H2020-EU.3. SOCIETAL CHALLENGES
H2020-EU.3.0. Cross-cutting call topics
H2020-EIC-SMEInst-2018-2020
H2020-SMEInst-2018-2020-1