Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

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Authors: Angela Oppelt, Daniel Kaschek, Suzanna Huppelschoten, Rowena Sison-Young, Fang Zhang, Marie Buck-Wiese, Franziska Herrmann, Sebastian Malkusch, Carmen L. Krüger, Mara Meub, Benjamin Merkt, Lea Zimmermann, Amy Schofield, Robert P. Jones, Hassan Malik, Marcel Schilling, Mike Heilemann, Bob van de Water, Christopher E. Goldring, B. Kevin Park, Jens Timmer, Ursula Klingmüller

Journal title: npj Systems Biology and Applications

Journal number: 4/1

Journal publisher: -

Published year: 2018

DOI identifier: 10.1038/s41540-018-0058-z

ISSN: 2056-7189