Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

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Authors: Imaide, S., Riching, K.M., Makukhin, N., Vetma, V., Whitworth, C., Hughes, S.J., Trainor, N., Mahan, S.D., Murphy, N., Cowan, A.D., Chan, K.-H., Craigon, C., Testa, A., Maniaci, C., Urh, M., Daniels, D.L.; Ciulli, A.

Journal title: Nature Chemical Biology

Journal publisher: Nature Publishing Group

Published year: 2021

DOI identifier: 10.1038/s41589-021-00878-4

ISSN: 1552-4450