Manuscript on chronic bleomycin MR&PET

An ARRIVE-compliant manuscript submitted for open-access publication which (a) characterizes the progression of bleomycin-induced lung inflammation and fibrosis in rats using suitable imaging biomarkers employing 1H-MRI and PET/CT using tracers for inflammation (e.g. FDG), and for structural change (e.g. collagen 1) (b) correlates imaging biomarkers with conventional evaluation such as histology, cells, and protein expression; If the studies are negative, report of the negative findings.Responsible: Lund/TrulyVerification: (1) Minutes of WP3 meeting (2) Pdf of manuscript; (3) Email from journal acknowledging receipt of manuscriptDate: M42GNG 3.3.G1 GO: PET/CT or MRI biomarkers improve the characterization of progression in rats of bleomycin-induced lung inflammation vs fibrosis. Verification: Minutes of WP3 Date: M24Consequence: If the imaging biomarkers are uninformative, NO-GO for multisite preclinical evaluation