Manuscript on imaging cellular vs non-cellular components

An ARRIVE-compliant manuscript submitted for open-access publication whichcharacterizes the set-up and characterization of cellular vs. non-cellular components of chronic bleomycin-induced lung fibrosis in rats using (a) suitable 1H-MRI and/or PET imaging biomarkers and (b) discusses implications for clinical assessment, (c) correlates imaging biomarkers with conventional evaluation such as histology, cells, protein expression and ‘lung function’. Reports to include also negative findings.Responsible for coordinating and assembling entire manuscript: Lund/TrulyVerification: (1) Minutes of WP3 meeting including prospective sample size calculation and prospective protocol; (2) Pdf of manuscript; (3) Email from journal acknowledging receipt of manuscriptGNG 3.3 G2: GO: Novel chronic bleomycin model improves the translatability of animal model to clinical setting. Imaging biomarkers suing MRI and/or PET/CT improve characterization of cellular vs. non-cellular components of bleomycin-induced lung fibrosis in a chronic rat model. Verification: (1) Minutes of WP3 meeting Consequence: If the imaging biomarkers are uninformative: NO-GO for multisite preclinical evaluation; NO-GO for progression into manDate: M36