in vivo animal models that induce peripheral nervous toxicities

This report will describe protocols for the assessment in vivo of animal models of peripheral neuropathies using defined toxicants the document will summarize results obtained with different compounds able to induce PNSTox studies of neurotoxicity and the informative endpoints for focused noninvasive detection In particular it will summarize results obtained in terms of behavioural evaluations sensorimotor parameters painrelated measures emotion cognitionrelated parameters or electrophysiological approaches evaluation of ototoxicity Histological correlates to the neuropathic functional alterations will be also reported Pharmacokinetic data relative to the drug exposure levels in plasmasera in comparison to peripheral nervous tissue will be reported