Candidate pathways and biological targets involved in P/P adverse effects

This report will organize and present scientific knowledge relating to Psychological Psychiatric PP adverse effects with particular focus on immunomodulation Knowledge will be organized in two groups existing knowledge and novel hypotheses In both cases knowledge will consist of a full mechanistic description of genes targets and pathways responsible for each selected toxicity i depression and suicidal ideation and behaviour which can be assessed in animals such as anhedonia aggression and impulsivity and ii memory disorders All supporting scientific evidence from renownedwellranked journals will be listed in the bibliography section The goal of this deliverable is to provide a single comprehensive collection of existing knowledge and some novel hypotheses around Psychological Psychiatric toxicity supporting researchers wishing to assess novel compounds for their risk to develop such adverse effects In particular the nature of the relationship between immunomodulation and PP adverse effects will be investigated