Sensitive biomarkers of neurotoxicity

This document will describe a list of PNSTox sensitive biomarker candidates based on behavioural histological and molecular parameters as well as from in silico predictions The results of omicbased analyses microRNAs and proteins on plasmasera samples during the neuropathy induction by neurotoxic drugs will be summarized A comparison of this data with functional and histological responses will be obtained Moreover the report will indicate a selection of available useful assays to measure the expression profile of translational biomarker candidates in seraplasma from retrospective and prospective studies across species rat dogs and nonhuman primates