Detailed review paper on state of the art on MDCs

A detailed review will be performed of the existing literature, databases and reports from ongoing sister projects in order to synthesize the available information on relevant exposures, molecular mechanisms and adverse health effects associated with exposure to MDCs. This will include a review of published information on in vitro and animal studies, as well as human epidemiological data on measured metabolic endpoints and biomarkers and association with exposure (UU). We will use where appropriate information available from HBM4EU, EUROMIX, and others. In HBM4EU, beneficiaries UU and VITO are involved in systematically evaluating and categorizing effect biomarkers for different health endpoints including metabolic disorders. This review will allow the prioritization of molecular initiating events (MIE), key effects and biological endpoints associated with metabolic disorders, and will provide an information base for the selection of MoA and biomarkers for subsequent analysis in WP1-5.