Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

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Authors: Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K. Griffin, Kanayo Satoh, David H. Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel A. Burguillos, Roger B. Dodd, Fusheng Chen, Yalun Zhang, Patrick Flagmeier, Lisa-Maria Needham, Masahiro Enomoto, Seema Qamar, James Henderson, Jochen Walter, Paul E. Fraser, David Klenerman, Steven F. Lee, Peter St George-Hyslop, Guy C. Brown

Journal title: Journal of Biological Chemistry

Journal number: 296

Journal publisher: American Society for Biochemistry and Molecular Biology Inc.

Published year: 2021

Published pages: 100631

DOI identifier: 10.1016/j.jbc.2021.100631

ISSN: 0021-9258