The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

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Authors: Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock, Christian Haass

Journal title: Molecular Neurodegeneration

Journal number: 13/1

Journal publisher: BioMed Central

Published year: 2018

DOI identifier: 10.1186/s13024-018-0280-6

ISSN: 1750-1326