Report on progress of the prospective at-risk RTCure cohort

Establish an RTCure prospective cohort of atrisk individualsWhile the analysis of already existing cohorts will allow us to obtain valuable information on the potential parameters which predict progression to RA the establishment of a new prospective cohort of atrisk individuals with contribution from all partners and with a harmonized mode of data acquisition will be an important step further which will allow i study of larger sample size of atrisk individuals with ii a higher possibility to better compare data based on standardized protocols of data acquisition and iii to provide a basis for future clinical trials see also WP6 For establishing this cohort the use of methods such as Multiple Randomised Controlled Trial MRCT design will be considered The plan is that each academic partner contributes at least 50 atrisk individuals to this joint RTCure cohort allowing a total number of at least 600 atrisk individuals with identical data collection to be studied by the RTCure consortium Immunomonitoring techniques applied and developed in WP3 and WP4 will also feed into this cohort